Description

3-(Trimethylsilyloxy)Estra-1,3,5(10)-Trien-17-One o-Methyl Oxime is a high-purity, advanced steroid derivative featuring a trimethylsilyloxy (TMS) protective group and an o-methyl oxime moiety. This compound is a critical pharmaceutical intermediate valued for its role in the synthesis of complex steroid-based active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development and production of steroidal drugs and hormone therapies.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of steroidal drugs and hormone-based active pharmaceutical ingredients (APIs).
• Steroid Research & Development: Used as a reference standard and a precursor in medicinal chemistry for exploring new therapeutic compounds.
• Hormone Analog Synthesis: Facilitates the creation of modified estrogen analogs for pharmacological studies and drug discovery.
• Process Chemistry: Employed in scale-up and optimization of synthetic routes for commercial pharmaceutical manufacturing.
• Academic Research: Serves as a specialized reagent in university and institutional labs for advanced organic and steroid chemistry.

Basic Information

Product Name	3-(Trimethylsilyloxy)Estra-1,3,5(10)-Trien-17-One o-Methyl Oxime
CAS No.	69688-21-7
Molecular Formula	C22H35NO2Si
Molecular Weight	373.61 g/mol
Synonyms	17-Oximino-3-trimethylsilyloxyestra-1,3,5(10)-triene; 3-TMS-Estrone Methyl Oxime; Estrone 3-TMS Ether Methyl Oxime; 3-(Trimethylsilyloxy)-17-(methoxyimino)estra-1,3,5(10)-triene; 3-TMS-O-Estrone Methyl Oxime; 3-Trimethylsilyloxyestra-1,3,5(10)-trien-17-one O-methyloxime; Estrone 3-(trimethylsilyl) ether O-methyloxime
EINECS	Contact for details

Quality Control

Our 3-(Trimethylsilyloxy)Estra-1,3,5(10)-Trien-17-One o-Methyl Oxime is manufactured under strict quality protocols. Each batch undergoes rigorous analytical testing, including HPLC and NMR, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality management system is designed to support cGMP compliance for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.