Description

N,n-Bis(Trimethylsilyl)-3-Pyridinecarboxamide is a specialized organosilicon reagent featuring a pyridinecarboxamide core protected by trimethylsilyl (TMS) groups. This compound is valued for its role as a versatile silylating agent and protected intermediate in advanced synthetic chemistry, particularly for modifying nucleophilic sites. It is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity building blocks for complex molecule synthesis, including active pharmaceutical ingredients (APIs) and functional polymers.

Application

• Pharmaceutical Intermediate: Serves as a key protected synthon in the multi-step synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the development and production of advanced pesticides and herbicides where silyl protection strategies are employed.
• Organometallic Chemistry: Acts as a ligand precursor or a silylating agent in catalytic systems and metal-organic framework (MOF) synthesis.
• Peptide & Nucleoside Chemistry: Facilitates the protection of sensitive functional groups during the synthesis of modified peptides and nucleoside analogs.
• Material Science Research: Employed in the surface functionalization of nanoparticles and the creation of silicon-containing polymers and hybrid materials.
• Analytical Derivatization: Used to silylate compounds for Gas Chromatography-Mass Spectrometry (GC-MS) analysis to improve volatility and detection.

Basic Information

Product Name	N,n-Bis(Trimethylsilyl)-3-Pyridinecarboxamide
CAS No.	69688-12-6
Molecular Formula	C14H26N2OSi2
Molecular Weight	294.55 g/mol
Synonyms	3-Pyridinecarboxamide, N,N-bis(trimethylsilyl)-; N,N-Bis(trimethylsilyl)nicotinamide; Nicotinamide, N,N-bis(trimethylsilyl)-; N,N-Bis(TMS)-3-pyridinecarboxamide; TMS-protected nicotinamide; Bis(trimethylsilyl)pyridine-3-carboxamide; 3-(Bis(trimethylsilyl)carbamoyl)pyridine
EINECS	Contact for details

Quality Control

Our N,n-Bis(Trimethylsilyl)-3-Pyridinecarboxamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.