Description

(5E,7E,22E)-3β-(Trimethylsiloxy)-9,10-Secoergosta-5,7,22-Triene CAS NO 69688-07-9 is a high-purity, synthetic sterol derivative, specifically a trimethylsilyl ether of a secoergostatriene. This compound serves as a critical advanced intermediate in the synthesis of vitamin D analogs and other high-value steroidal pharmaceuticals. It is essential for research and development laboratories and production facilities focused on endocrinology, bone metabolism therapeutics, and novel drug discovery. The compound's defined stereochemistry and functional group make it a valuable building block for creating targeted bioactive molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the multi-step synthesis of active vitamin D metabolites (e.g., calcitriol, tacalcitol) and their analogs.
• Research Chemical: Used in academic and industrial R&D for studying vitamin D receptor (VDR) pathways, structure-activity relationships (SAR), and metabolic processes.
• Process Development: Serves as a standard or starting material for optimizing scalable synthesis routes for sterol-based active pharmaceutical ingredients (APIs).
• Biochemical Tool: Employed in the development of assays and diagnostic methods related to calcium homeostasis and bone health.
• Fine Chemical Synthesis: Building block for creating novel steroidal compounds with potential applications in oncology, dermatology, and immunology.

Basic Information

Product Name	(5E,7E,22E)-3β-(Trimethylsiloxy)-9,10-Secoergosta-5,7,22-Triene
CAS No.	69688-07-9
Molecular Formula	C31H52OSi
Molecular Weight	468.83 g/mol
Synonyms	3β-Trimethylsiloxy-9,10-secoergosta-5,7,22-triene; (5E,7E,22E)-3β-(Trimethylsilyloxy)-9,10-secoergosta-5,7,22-triene; 3β-[(Trimethylsilyl)oxy]-9,10-secoergosta-5,7,22-triene; TMS ether of 9,10-Secoergosta-5,7,22-trien-3β-ol; Vitamin D3 TMS Ether Intermediate; Ergocalciferol TMS Derivative; Sterol TMS Ether
EINECS	Contact for details

Quality Control

Our (5E,7E,22E)-3β-(Trimethylsiloxy)-9,10-Secoergosta-5,7,22-Triene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and stereochemical integrity. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment. We support compliance with cGMP, ICH guidelines, and other relevant pharmaceutical quality standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent degradation. Keep away from strong bases and incompatible organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Any Single Unknown Impurity	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.