Description

16β,17β-[Isopropylidenebis(Oxy)]-3-(Trimethylsiloxy)-1,3,5(10)-Estratriene is a high-purity, advanced pharmaceutical intermediate characterized by its specific steroidal structure with protective siloxy and acetonide groups. This compound is critical for ensuring the precise synthesis and structural integrity of complex active pharmaceutical ingredients (APIs) in the final manufacturing steps. It is primarily required by R&D laboratories and production facilities in the pharmaceutical and biotechnology sectors for the development and scale-up of steroidal drugs and other specialized therapeutics.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of steroidal active pharmaceutical ingredients (APIs).
• Steroid Derivative Synthesis: Used in research and production to introduce specific functional groups or create novel steroid analogs for biological testing.
• Hormone Research: Serves as a precursor or reference standard in biochemical and endocrinological research studies.
• Process Chemistry: Employed in process development and optimization for the commercial manufacturing of complex organic molecules.
• GMP Manufacturing: Suitable for use in cGMP-compliant production environments for regulated pharmaceutical products.

Basic Information

Product Name	16β,17β-[Isopropylidenebis(Oxy)]-3-(Trimethylsiloxy)-1,3,5(10)-Estratriene
CAS No.	69688-05-7
Molecular Formula	C25H38O4Si
Molecular Weight	430.66 g/mol
Synonyms	3-(Trimethylsilyloxy)-16β,17β-isopropylidenedioxyestra-1,3,5(10)-triene; 3-Trimethylsiloxy-16β,17β-isopropylidenedioxyestra-1,3,5(10)-triene; 16β,17β-Isopropylidenedioxy-3-trimethylsilyloxyestra-1,3,5(10)-triene; Estratriene-3-ol, 16,17-isopropylidenedioxy-, 3-(trimethylsilyl) ether; 16β,17β-O-Isopropylidene-3-O-trimethylsilylestra-1,3,5(10)-triene
EINECS	Contact for details

Quality Control

Every batch of 16β,17β-[Isopropylidenebis(Oxy)]-3-(Trimethylsiloxy)-1,3,5(10)-Estratriene is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and consistency, supporting its use in critical pharmaceutical applications. A detailed Certificate of Analysis (COA) with specifications for identity (IR, NMR), assay (HPLC), and impurity profile is available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed in a dry environment and opened under controlled conditions to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Any single impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.