Description

14-Hydroxy-3-(Trimethylsiloxy)-1,3,5(10)-Estratrien-17-One is a key steroidal intermediate, specifically a silyl-protected derivative of estradiol. This compound matters for its role in the efficient, multi-step synthesis of complex pharmaceutical actives, offering a protected hydroxyl group that enhances reaction selectivity and yield. It is primarily needed by research institutions and manufacturers in the pharmaceutical industry developing hormone therapies, oncology drugs, and other advanced steroid-based medications.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of steroidal active pharmaceutical ingredients (APIs).
• Hormone Analog Development: Used in research and production of novel estrogen receptor modulators and hormone replacement therapies.
• Oncological Drug Synthesis: Serves as a precursor in the manufacture of certain anticancer agents targeting hormone-sensitive cancers.
• Process Chemistry: Valued in scalable manufacturing for its protective group chemistry, enabling cleaner and more efficient synthetic routes.
• Biochemical Research: Employed in academic and industrial laboratories for studying steroid metabolism and receptor interactions.
• Reference Standard: Can be utilized as a high-purity analytical standard for quality control in steroid manufacturing.

Basic Information

Product Name	14-Hydroxy-3-(Trimethylsiloxy)-1,3,5(10)-Estratrien-17-One
CAS No.	69597-46-2
Molecular Formula	C21H32O3Si
Molecular Weight	360.57 g/mol
Synonyms	14-Hydroxy-3-(trimethylsilyloxy)estra-1,3,5(10)-trien-17-one; 3-(Trimethylsiloxy)-14-hydroxyestra-1,3,5(10)-trien-17-one; Estra-1,3,5(10)-trien-17-one, 14-hydroxy-3-(trimethylsilyloxy)-; 14-Hydroxyestradiol 3-trimethylsilyl ether; 14-Hydroxy-3-O-trimethylsilylestrone; TMS-Protected 14-Hydroxyestradiol Derivative
EINECS	Contact for details

Quality Control

Our 14-Hydroxy-3-(Trimethylsiloxy)-1,3,5(10)-Estratrien-17-One is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting full specifications are available upon request. We support compliance with cGMP and ICH Q7 guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.