Description

Benzenamine, 2-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]- is a protected aniline derivative, specifically a tert-butyldimethylsilyl (TBDMS) ether of 2-aminophenol, serving as a crucial synthetic intermediate in advanced organic chemistry. Its primary value lies in providing a protected amine and phenol functionality, enabling selective reactions and enhancing the stability of sensitive intermediates during multi-step synthesis. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries engaged in developing active pharmaceutical ingredients (APIs), complex natural products, and novel materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug molecules, particularly those requiring selective protection/deprotection strategies.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the protected aminophenol moiety is incorporated into the final active ingredient.
• Organic Ligand Precursor: Serves as a starting material for the synthesis of sophisticated ligands used in catalysis and coordination chemistry.
• Material Science Research: Employed in the creation of novel polymers, dyes, and functional organic materials with specific optical or electronic properties.
• Peptide Mimetics & Conjugation Chemistry: Facilitates the synthesis of peptide analogs and bioconjugates by providing a handle for selective chemical modification.
• Academic & R&D Laboratories: A valuable reagent for methodological development and exploratory synthesis in university and industrial research settings.

Basic Information

Product Name	Benzenamine, 2-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-
CAS No.	69589-21-5
Molecular Formula	C₁₂H₂₁NOSi
Molecular Weight	223.39 g/mol
Synonyms	2-[(tert-Butyldimethylsilyl)oxy]aniline; 2-Aminophenyl tert-butyldimethylsilyl ether; 2-(TBDMS-Oxy)aniline; N-TBDMS Protected 2-aminophenol; 2-[(1,1-Dimethylethyl)dimethylsilyl]oxy-Benzenamine; 2-ATBDMS; tert-Butyldimethyl(2-aminophenoxy)silane
EINECS	Contact for details

Quality Control

Our production of Benzenamine, 2-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]- adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research and scale-up applications. Each lot undergoes comprehensive analysis, including identity confirmation by spectroscopic methods (IR, NMR) and purity assessment by chromatographic techniques (HPLC, GC). A detailed Certificate of Analysis (COA) documenting identity, assay, and impurity profiles is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, containers should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.