Description

2,2-Dimethylbutanoic Acid, 3-Trimethylsilyloxy-, Ethyl Ester is a specialized organosilicon compound that serves as a valuable protected intermediate in advanced organic synthesis. Its core value lies in the dual functionality of the silyl ether and ester groups, which provide orthogonal protection strategies and enable precise synthetic transformations. This high-purity reagent is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable building blocks for complex molecule construction.

Application

• Pharmaceutical Intermediate: A key protected synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for introducing branched alkyl acid motifs.
• Agrochemical Synthesis: Used in the development of advanced herbicides and fungicides where the specific steric profile of the 2,2-dimethylbutanoate moiety is required.
• Flavor & Fragrance Chemistry: Acts as a precursor for esters and acids that contribute to unique, long-lasting fruity and green olfactory notes in high-end fragrance compositions.
• Polymer Modification: Employed as a functional monomer or chain-transfer agent to introduce hydrolytically stable, bulky side chains into specialty polymers, influencing thermal and mechanical properties.
• Organic Synthesis Reagent: Utilized in methodologies such as Mukaiyama aldol reactions or as a silyl enol ether equivalent for controlled C-C bond formation under mild conditions.
• Liquid Crystal & Electronic Materials: Serves as a synthetic intermediate for mesogenic compounds and organic semiconductors where precise steric control is critical for material performance.

Basic Information

Product Name	2,2-Dimethylbutanoic Acid, 3-Trimethylsilyloxy-, Ethyl Ester
CAS No.	69382-53-2
Molecular Formula	C11H24O3Si
Molecular Weight	232.40 g/mol
Synonyms	Ethyl 3-(Trimethylsilyloxy)-2,2-dimethylbutanoate; 2,2-Dimethyl-3-(trimethylsilyloxy)butyric Acid Ethyl Ester; 3-(Trimethylsiloxy)-2,2-dimethylbutyric Acid Ethyl Ester; Ethyl 2,2-Dimethyl-3-trimethylsilyloxybutyrate; TMS Ether of Ethyl 3-Hydroxy-2,2-dimethylbutyrate; Ethyl 3-Hydroxy-2,2-dimethylbutyrate TMS Ether; 3-[(Trimethylsilyl)oxy]-2,2-dimethylbutanoic Acid Ethyl Ester
EINECS	Contact for details

Quality Control

Our 2,2-Dimethylbutanoic Acid, 3-Trimethylsilyloxy-, Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our production adheres to cGMP guidelines where applicable, ensuring consistency and traceability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.420 - 1.430
Density (20°C)	0.88 - 0.92 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.