Description

4-Bromo-1-Trimethylsilyl-1-Butyne is a versatile organosilicon building block featuring both a bromo and a terminal alkyne functionality protected by a trimethylsilyl (TMS) group. This compound is highly valued in advanced organic synthesis for its dual reactivity, enabling sequential cross-coupling and deprotection steps. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing acetylene or substituted aromatic/heteroaromatic rings via Sonogashira and other cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and plant growth regulators that require alkyne-based scaffolds.
• Material Science & Polymer Chemistry: Serves as a monomer or functionalization agent in the production of specialty polymers, dendrimers, and conductive organic materials.
• Ligand & Catalyst Development: Employed in the preparation of novel phosphine or N-heterocyclic carbene (NHC) ligands where the alkyne moiety is integral to the ligand backbone.
• Chemical Biology & Bioconjugation: Useful for "click chemistry" applications after TMS deprotection, enabling the labeling and modification of biomolecules.
• Organic Electronic Materials: A precursor for small molecules used in organic light-emitting diodes (OLEDs) and organic photovoltaics (OPVs).

Basic Information

Product Name	4-Bromo-1-Trimethylsilyl-1-Butyne
CAS No.	69361-41-7
Molecular Formula	C7H13BrSi
Molecular Weight	205.17 g/mol
Synonyms	1-Bromo-4-(trimethylsilyl)-3-butyne; 4-Bromo-1-(trimethylsilyl)-1-butyne; 3-Butyn-1-yltrimethylsilane, 1-bromo-; 1-Trimethylsilyl-4-bromo-1-butyne; TMS-Protected 4-Bromo-1-butyne; (4-Bromobut-1-yn-1-yl)trimethylsilane; Bromo(trimethylsilyl)butyne
EINECS	Contact for details

Quality Control

Our 4-Bromo-1-Trimethylsilyl-1-Butyne is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including GC, NMR, and HPLC, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.