Description

3',5'-o-(1,1,3,3-Tetraisopropyl-1,3-Disiloxanediyl)Guanosine is a high-purity, protected nucleoside derivative, specifically designed as a critical building block for oligonucleotide synthesis. This compound is essential for researchers and manufacturers requiring precise control over nucleic acid sequences in therapeutic and diagnostic applications. It is primarily utilized in the pharmaceutical and biotechnology industries for the development of antisense oligonucleotides, siRNA, and other advanced nucleic acid-based therapies.

Application

• Solid-Phase Oligonucleotide Synthesis (SPOS): Serves as a key phosphoramidite precursor for the automated synthesis of DNA and RNA strands.
• Antisense Oligonucleotide (ASO) Development: Used in the research and production of ASO drugs targeting genetic diseases.
• Small Interfering RNA (siRNA) Manufacturing: A fundamental monomer for constructing siRNA duplexes used in gene silencing applications.
• Diagnostic Probe Synthesis: Employed in creating labeled probes for PCR, sequencing, and microarray technologies.
• Research & Development: Used in academic and industrial labs for studying nucleic acid chemistry and developing novel therapeutic modalities.
• GMP-grade Pharmaceutical Production: Supplied as a raw material for the cGMP manufacturing of oligonucleotide active pharmaceutical ingredients (APIs).

Basic Information

Product Name	3',5'-o-(1,1,3,3-Tetraisopropyl-1,3-Disiloxanediyl)Guanosine
CAS No.	69304-44-5
Molecular Formula	C23H41N5O6Si2
Molecular Weight	539.78 g/mol
Synonyms	Guanosine, 2'-deoxy-2'-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)-; 2'-Deoxy-2'-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)guanosine; 3',5'-O-(Tetraisopropyldisiloxane-1,3-diyl)guanosine; TIPDS-Guanosine; Guanosine 3',5'-cyclic tetraisopropyldisiloxane; N2-Isobutyryl-3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)guanosine (common protected form); 5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)guanosine
EINECS	Contact for details

Quality Control

Our 3',5'-o-(1,1,3,3-Tetraisopropyl-1,3-Disiloxanediyl)Guanosine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and LC-MS for identity verification, to ensure it meets the stringent requirements for oligonucleotide synthesis. Certificates of Analysis (COA) with full traceability are provided. We can supply material compliant with research-grade through to cGMP standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, freezer. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.