Description

Deoxypodophyllotoxin is a potent aryltetralin lignan derivative and a key intermediate in the synthesis of various biologically active compounds. Its structural framework serves as a critical scaffold for developing novel pharmaceutical agents, particularly in oncology and antiviral research. This high-purity compound is essential for research institutions, pharmaceutical development laboratories, and fine chemical manufacturers engaged in advanced synthetic chemistry and drug discovery programs.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor for the semi-synthesis of potent chemotherapeutic agents like etoposide and teniposide.
• Anticancer Research: Used as a reference standard and active compound in studies targeting tubulin polymerization inhibition and topoisomerase II.
• Antiviral Agent Development: Investigated for its potential as a lead compound in the development of treatments for viral infections.
• Biochemical Tool Compound: Employed in cell biology and pharmacology research to study cell cycle arrest and apoptosis mechanisms.
• Natural Product Synthesis: A fundamental building block for the total synthesis of complex natural products within the podophyllotoxin family.
• Reference Standard: Used in analytical laboratories for quality control and method development via HPLC or LC-MS.

Basic Information

Product Name	Deoxypodophyllotoxin
CAS No.	69222-20-4
Molecular Formula	C22H22O7
Molecular Weight	398.41 g/mol
Synonyms	Deoxypodophyllotoxin; (-)-Deoxypodophyllotoxin; Anthricin; NSC 334088; 5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one; 4'-Demethylepipodophyllotoxin; 4'-Demethylpodophyllotoxin (ambiguous, verify structure)
EINECS	Contact for details

Quality Control

Our Deoxypodophyllotoxin is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity determination, IR and NMR for structural confirmation, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). For long-term storage, consider storing under inert atmosphere at 2-8°C to maximize stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.