Description

2-Naphthalenol, 3-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]-2,3,4,4A,5,6,7,8-Octahydro-1,4A-Dimethyl-7-(1-Methylethenyl)-, [2R-(2Alpha,3Alpha,4Aalpha,7Alpha] is a high-purity, stereochemically defined intermediate featuring a tert-butyldimethylsilyl (TBDMS) protecting group. This compound is critical for enabling complex synthetic routes where selective protection and deprotection of hydroxyl groups are required under mild conditions. It is primarily utilized by research institutions and pharmaceutical manufacturers in the development and production of advanced active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral building block in the multi-step synthesis of complex drug molecules, particularly in steroid and terpenoid-related therapeutic areas.
• Organic Synthesis Research: Used in academic and industrial R&D for developing novel synthetic methodologies, especially those involving silyl ether protecting group chemistry.
• Asymmetric Catalysis Studies: Serves as a substrate or ligand precursor in the development and testing of new chiral catalysts.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, agrochemicals, and high-value fragrance compounds requiring precise stereochemical control.
• Process Chemistry Development: Used for scaling up synthetic routes from laboratory to pilot plant and commercial production, where its defined purity and stability are essential.

Basic Information

Product Name	2-Naphthalenol, 3-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]-2,3,4,4A,5,6,7,8-Octahydro-1,4A-Dimethyl-7-(1-Methylethenyl)-, [2R-(2Alpha,3Alpha,4Aalpha,7Alpha]
CAS No.	68961-96-6
Molecular Formula	C21H36O2Si
Molecular Weight	348.60 g/mol
Synonyms	(2R,3R,4aR,7R)-3-[(tert-Butyldimethylsilyl)oxy]-1,4a-dimethyl-7-(prop-1-en-2-yl)-1,2,3,4,4a,5,6,7-octahydronaphthalen-2-ol; 3-[(tert-Butyldimethylsilyl)oxy] Podocarp-8(14)-en-13-ol Derivative; TBDMS Ether of a Dihydroxylated Diterpenoid; Steroid TBDMS Intermediate; (2α,3α,4aα,7α)-3-[(tert-Butyldimethylsilyl)oxy]-1,4a-dimethyl-7-isopropenyl-decahydronaphthalen-2-ol; CAS 68961-96-6
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and scale-up processes. Identity, purity, and stereochemical integrity are confirmed through a battery of analytical techniques including HPLC, GC, NMR, and chiral analysis. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The product is light-sensitive and should be stored away from strong bases and organic solvents. Keep the container tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.