Description

(R)-Benzyl 2-Amino-4-Methylpentanoate Hydrochloride CAS NO 68838-94-8 is a high-purity chiral building block and protected amino acid derivative, essential for advanced organic synthesis. Its primary value lies in providing a stereochemically defined, readily functionalizable L-leucine analog for the construction of complex peptides and pharmaceutical intermediates. This compound is critically needed by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for developing novel therapeutics and bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of protease inhibitors, peptidomimetics, and other active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used as a protected amino acid derivative in solid-phase and solution-phase peptide synthesis, particularly where the side chain of leucine is required.
• Bioconjugation & Labeling: Serves as a precursor for creating labeled peptides or conjugates for diagnostic and research applications.
• Asymmetric Catalysis Research: Employed as a substrate or ligand precursor in the development and study of asymmetric catalytic reactions.
• Chemical Biology Probes: Utilized in the design and synthesis of chemical probes to study enzyme function and protein-protein interactions.
• Fine Chemical Production: Acts as a building block for the manufacture of specialty chemicals, flavors, and fragrances requiring specific chirality.

Basic Information

Product Name	(R)-Benzyl 2-Amino-4-Methylpentanoate Hydrochloride
CAS No.	68838-94-8
Molecular Formula	C14H22ClNO2
Molecular Weight	271.78 g/mol
Synonyms	H-Leu-OBzl.HCl; (R)-Benzyl leucinate hydrochloride; L-Leucine benzyl ester hydrochloride; Benzyl L-leucinate hydrochloride; (2R)-2-Amino-4-methylpentanoic acid phenylmethyl ester hydrochloride; (R)-2-Amino-4-methyl-pentanoic acid benzyl ester hydrochloride; (R)-Benzyl 2-amino-4-methylvalerate hydrochloride; L-Leucine benzyl ester monohydrochloride
EINECS	Contact for details

Quality Control

Our (R)-Benzyl 2-Amino-4-Methylpentanoate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity, and specific impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.