Description

5-Methyltetrahydrofolic Acid Disodium Salt is the stable, bioavailable, and sodium-stabilized form of the essential B-vitamin folate. This high-purity compound is critical for ensuring precise and reliable folate activity in advanced nutritional and pharmaceutical formulations. It is primarily required by manufacturers in the nutraceutical, pharmaceutical, and clinical nutrition sectors for producing premium-grade supplements, fortified foods, and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Active Ingredient (API): Used in prescription medications and injectables for folate deficiency treatment and metabolic support.
• Premium Nutraceutical Formulations: A key ingredient in high-efficacy dietary supplements, prenatal vitamins, and methylation support products.
• Clinical & Medical Nutrition: Incorporated into medical foods and enteral/parenteral nutrition solutions for patients with specific metabolic needs.
• Food & Beverage Fortification: Employed for the stable fortification of foods and beverages, including infant formula and meal replacements.
• Biochemical Research & Diagnostics: Serves as a critical standard and reagent in life science research, clinical assays, and enzymatic studies.
• Cell Culture Media: Used as a component in specialized cell culture media for biotechnology and pharmaceutical research applications.

Basic Information

Product Name	5-Methyltetrahydrofolic Acid Disodium Salt
CAS No.	68792-52-9
Molecular Formula	C20H23N7Na2O6
Molecular Weight	503.43 g/mol
Synonyms	(6S)-5-Methyl-5,6,7,8-tetrahydrofolic acid disodium salt; L-Methylfolate Disodium; Metafolin® (Brand Name); 5-MTHF Disodium; 5-Methyltetrahydrofolate Disodium; (6S)-5-Methyltetrahydrofolate Disodium Salt; 5-Methyl-THF Na2; Vitamin B9 (active form) Disodium Salt
EINECS	Contact for details

Quality Control

Our 5-Methyltetrahydrofolic Acid Disodium Salt is manufactured under strict quality systems. Each batch is tested to ensure compliance with high-purity standards suitable for pharmaceutical and nutraceutical applications. We provide comprehensive Certificates of Analysis (COA) detailing purity, isomer content, and impurity profiles, supporting compliance with cGMP, USP, and FCC guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept sealed under inert atmosphere (nitrogen) after opening to maintain stability and potency.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 97.0% (on anhydrous basis)
Isomeric Purity ((6S)-Isomer)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 10 ppm
Microbiological Analysis	Meets Ph. Eur. / USP criteria

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.