Description

Levomefolic Acid is the biologically active, metabolically reduced form of folic acid (vitamin B9). This compound matters because it is the primary form utilized by the human body for critical biochemical processes, including DNA synthesis and methylation, offering superior bioavailability compared to synthetic folic acid. It is essential for manufacturers in the pharmaceutical, nutraceutical, and premium dietary supplement industries seeking to develop advanced prenatal, cardiovascular, and cognitive health formulations.

Application

• Pharmaceutical Active Ingredient (API): Core component in prescription medications for treating folate deficiency and supporting prenatal health.
• Premium Dietary Supplements: Key ingredient in high-bioavailability multivitamins, prenatal vitamins, and specialized nutraceuticals targeting methylation support.
• Clinical Nutrition: Used in medical food and enteral formulas designed for patients with specific metabolic needs or malabsorption issues.
• Food Fortification (Advanced Applications): Potential use in functional foods and beverages where a highly bioavailable folate source is required, subject to regional regulatory approval.
• Research & Development: Standard reference material for biochemical, nutritional, and pharmacological studies.

Basic Information

Product Name	Levomefolic Acid
CAS No.	31690-09-2
Molecular Formula	C₂₀H₂₅N₇O₆
Molecular Weight	459.46 g/mol
Synonyms	(6S)-5-Methyltetrahydrofolic acid; (6S)-5-Methyltetrahydrofolate; L-Methylfolate; Metafolin® (brand name); 5-MTHF; 5-Methyltetrahydrofolate; (6S)-5-Methyl-5,6,7,8-tetrahydrofolic acid; Active folate
EINECS	Contact for details

Quality Control

Our Levomefolic Acid is manufactured under strict quality systems. We provide material that meets high-purity standards suitable for pharmaceutical and nutraceutical applications. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available for every batch. Our quality commitment ensures reliable supply and consistent performance in your formulations.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen) at a controlled room temperature of 15-25°C (59-77°F) to minimize oxidation. The container should be kept in a cool, dry, and well-ventilated area, separate from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation	[α]²⁰D: Specific range provided on COA
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤ 20 ppm
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.