Description

Cetotiamine is a synthetic thiamine (vitamin B1) derivative, specifically a disulfide prodrug, with the CAS registry number 137-76-8. This compound is valued for its enhanced stability and bioavailability compared to thiamine hydrochloride, making it a critical intermediate in advanced pharmaceutical synthesis. It is primarily required by manufacturers in the nutraceutical and pharmaceutical industries for the development of high-potency vitamin supplements and therapeutic formulations targeting thiamine deficiency.

Application

• Pharmaceutical Intermediates: Key starting material (KSM) or advanced intermediate in the synthesis of prescription-grade thiamine supplements and injectable formulations.
• Nutraceutical Manufacturing: Used in the production of high-end dietary supplements and functional foods designed for superior vitamin B1 delivery and absorption.
• Veterinary Medicine: Incorporated into vitamin premixes and therapeutic feeds for livestock and companion animals to prevent and treat thiamine deficiency disorders.
• Research & Development: Serves as a reference standard and biochemical reagent in metabolic studies, pharmacokinetic research, and analytical method development.
• Cosmeceuticals: Potential ingredient in specialized skincare products aimed at improving cellular energy metabolism and antioxidant defense in skin cells.

Basic Information

Product Name	Cetotiamine
CAS No.	137-76-8
Molecular Formula	C₁₇H₂₆N₄O₃S₂
Molecular Weight	398.54 g/mol
Synonyms	O,S-Diacetylthiamine; Thiamine Diacetate Disulfide; Cetotiaminum; Acefylline Piperazine; Vitamin B1 Disulfide Derivative; B1 Prodrug; Thiamine Tetrahydrofurfuryl Disulfide (related compound); TTFD Analog
EINECS	205-304-5

Quality Control

Our Cetotiamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling via HPLC and IR spectroscopy, to ensure it meets stringent specifications for pharmaceutical and nutraceutical use. Certificates of Analysis (COA) documenting compliance with agreed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	98.0% - 102.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.