Description

Trimethylsilyl Nonafluorobutanesulfonate is a highly reactive organosilicon reagent featuring a super-leaving group. This compound is a powerful silylating agent, prized for its ability to introduce the trimethylsilyl (TMS) protecting group under mild conditions. It is essential for synthetic chemists in pharmaceutical R&D and advanced material science, where precise control over functional group protection and deprotection is critical. Its unique perfluorinated sulfonate moiety provides exceptional reactivity and stability in demanding synthetic sequences.

Application

• Protecting Group Chemistry: Selective silylation of alcohols, phenols, carboxylic acids, and amines in complex molecule synthesis.
• Pharmaceutical Intermediates: Key reagent in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for sensitive or sterically hindered substrates.
• Polymer & Material Science: Used in the surface modification of inorganic materials and the synthesis of specialized silicone-based polymers and coatings.
• Catalyst & Ligand Synthesis: Preparation of silylated catalysts and ligands for organometallic chemistry and asymmetric catalysis.
• Analytical Derivatization: Agent for derivatizing compounds in Gas Chromatography (GC) and Mass Spectrometry (MS) to improve volatility and detection.
• Electrolyte Additives: Research component in the formulation of advanced electrolytes for lithium-ion batteries.

Basic Information

Product Name	Trimethylsilyl Nonafluorobutanesulfonate
CAS No.	68734-62-3
Molecular Formula	C7H9F9O3SSi
Molecular Weight	396.27 g/mol
Synonyms	Trimethylsilyl Perfluorobutanesulfonate; TMS Nonaflyate; Nonafluorobutanesulfonic Acid Trimethylsilyl Ester; (Trimethylsilyl) Nonafluorobutane-1-sulfonate; TMSONf; Trimethylsilyl Triflate Analog (C4F9); TMS Nonaflate
EINECS	Contact for details

Quality Control

Our Trimethylsilyl Nonafluorobutanesulfonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, GC, and HPLC, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to maintain stability and prevent hydrolysis.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.