Description

5-o-(tert-Butyldimethylsilyl)-2,3-o-Isopropylidene-D-Ribofuranose CAS NO 68703-51-5 is a key protected ribofuranose derivative, a vital chiral building block in organic synthesis. Its primary value lies in providing a versatile, selectively protected sugar scaffold for the controlled construction of complex nucleoside analogs and other bioactive molecules. This compound is essential for pharmaceutical R&D and fine chemical synthesis, particularly in the development of antiviral and anticancer therapeutics.

Application

• Nucleoside & Nucleotide Synthesis: A crucial intermediate for constructing modified ribose backbones in antiviral and anticancer drug candidates.
• Pharmaceutical Intermediates: Serves as a protected chiral synthon in multi-step syntheses of complex active pharmaceutical ingredients (APIs).
• Carbohydrate Chemistry: Used in the preparation of selectively protected sugars for glycosylation studies and oligosaccharide synthesis.
• Antiviral Pro-drug Development: Particularly relevant for the synthesis of modified nucleosides used in treatments for hepatitis C (HCV) and other viral infections.
• Biochemical Research: Employed as a substrate or intermediate in enzymatic studies and metabolic pathway investigations.
• Labeled Compound Synthesis: Acts as a starting material for the preparation of isotopically labeled (e.g., C13, deuterated) sugars for metabolic tracing.

Basic Information

Product Name	5-o-(tert-Butyldimethylsilyl)-2,3-o-Isopropylidene-D-Ribofuranose
CAS No.	68703-51-5
Molecular Formula	C14H28O5Si
Molecular Weight	304.46 g/mol
Synonyms	1,2-O-Isopropylidene-5-O-(tert-butyldimethylsilyl)-α-D-ribofuranose; 5-O-TBDMS-2,3-O-isopropylidene-D-ribofuranose; 5-O-(tert-Butyldimethylsilyl)-1,2-O-isopropylidene-α-D-ribofuranose; 5-O-TBDMS-1,2-O-isopropylidene-α-D-ribofuranose; TBDMS-protected isopropylidene ribose; D-Ribofuranose, 5-O-[(1,1-dimethylethyl)dimethylsilyl]-2,3-O-(1-methylethylidene)-; 5-O-(tert-Butyldimethylsilyl)-2,3-O-isopropylidene-D-ribose
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Quality Control

Our 5-o-(tert-Butyldimethylsilyl)-2,3-o-Isopropylidene-D-Ribofuranose is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical R&D. We provide comprehensive analytical data, including HPLC purity, chiral purity, and identity confirmation via NMR and mass spectrometry. Certificates of Analysis (COA) are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect stability and performance. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.