Description

(S)-[2,8-Bis(Trifluoromethyl)Quinolin-4-Yl]-[(2R)-2-Piperidyl]Methanol Hydrochloride is a high-purity, chiral pharmaceutical intermediate of significant commercial and research interest. This compound is valued for its role as a key building block in the synthesis of advanced active pharmaceutical ingredients (APIs), particularly those targeting complex therapeutic areas. It is primarily sought by pharmaceutical R&D laboratories, process development chemists, and fine chemical manufacturers engaged in the production of novel drug candidates.

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the multi-step synthesis of potential drug candidates, especially in medicinal chemistry programs.
• API Synthesis: Used in the development and scale-up of Active Pharmaceutical Ingredients (APIs) requiring a sophisticated quinoline-piperidine structural motif.
• Asymmetric Catalysis Research: Serves as a valuable substrate or ligand in studies exploring new asymmetric synthetic methodologies.
• Chemical Biology Probes: Utilized in the design and construction of molecular probes for investigating biological targets and pathways.
• Process Chemistry Development: Employed for route scouting, optimization, and the establishment of robust, scalable manufacturing processes.
• Reference Standard: Acts as a high-purity analytical standard for quality control and regulatory submissions in pharmaceutical development.

Basic Information

Product Name	(S)-[2,8-Bis(Trifluoromethyl)Quinolin-4-Yl]-[(2R)-2-Piperidyl]Methanol Hydrochloride
CAS No.	68682-28-0
Molecular Formula	C19H17ClF6N2O
Molecular Weight	438.80 g/mol
Synonyms	(S)-[2,8-Bis(trifluoromethyl)-4-quinolyl][(2R)-2-piperidyl]methanol hydrochloride; (S)-[2,8-Bis(trifluoromethyl)quinolin-4-yl][(2R)-piperidin-2-yl]methanol HCl; (S)-[2,8-Bis(trifluoromethyl)quinolin-4-yl]-((R)-piperidin-2-yl)methanol hydrochloride; (S)-[2,8-Bis(trifluoromethyl)quinolin-4-yl]-[(2R)-2-piperidinyl]methanol hydrochloride; (S)-[2,8-Bis(trifluoromethyl)quinolin-4-yl]-[(2R)-2-piperidyl]methanol HCl; (S)-[2,8-Bis(trifluoromethyl)quinolin-4-yl]-[(2R)-piperidin-2-yl]methanol hydrochloride; (S)-[2,8-Bis(trifluoromethyl)quinolin-4-yl]-[(R)-piperidin-2-yl]methanol hydrochloride; (S)-[2,8-Bis(trifluoromethyl)quinolin-4-yl][(2R)-2-piperidyl]methanol hydrochloride
EINECS	Contact for details

Quality Control

Our production of (S)-[2,8-Bis(Trifluoromethyl)Quinolin-4-Yl]-[(2R)-2-Piperidyl]Methanol Hydrochloride adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. All material is fully characterized and undergoes rigorous analytical testing, including chiral purity verification. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.