Description

2-Chloro-5-Nitrophenyl Isocyanate is a versatile aromatic isocyanate building block, primarily valued for its dual reactive sites that enable the synthesis of complex heterocyclic and functionalized molecular architectures. Its significance lies in providing a direct route to incorporate both a chloro and a nitro substituent pattern into target molecules, which is crucial for developing compounds with specific electronic and steric properties. This intermediate is essential for researchers and manufacturers in the agrochemical and pharmaceutical sectors, particularly for synthesizing advanced active ingredients and novel chemical entities.

Application

• Agrochemical Intermediate: A key precursor in the synthesis of modern herbicides, fungicides, and insecticides, where the chloro and nitro groups contribute to biological activity and binding affinity.
• Pharmaceutical Synthesis: Used as a critical building block for constructing urea and carbamate derivatives, which are common pharmacophores in drug discovery for various therapeutic areas.
• Polymer Chemistry: Serves as a monomer or cross-linking agent in the production of specialty polyurethanes and polyureas with enhanced thermal or chemical resistance properties.
• Dye and Pigment Manufacturing: Employed in the synthesis of complex azo dyes and organic pigments, where it helps introduce specific color properties and stability.
• Chemical Research & Development: A valuable reagent in academic and industrial R&D for exploring new reactions and creating libraries of novel chemical compounds for screening.
• Ligand and Catalyst Design: Useful for synthesizing specialized ligands used in coordination chemistry and catalysis, leveraging its isocyanate group for facile functionalization.

Basic Information

Product Name	2-Chloro-5-Nitrophenyl Isocyanate
CAS No.	68622-16-2
Molecular Formula	C7H3ClN2O3
Molecular Weight	198.56 g/mol
Synonyms	1-Chloro-2-isocyanato-4-nitrobenzene; 2-Chloro-5-nitrobenzenisocyanate; 4-Nitro-2-chlorophenyl isocyanate; (2-Chloro-5-nitrophenyl)isocyanate; Isocyanic acid, 2-chloro-5-nitrophenyl ester; 2-Chloro-5-nitro-phenyl isocyanate; NSC 163976
EINECS	Contact for details

Quality Control

Our production of 2-Chloro-5-Nitrophenyl Isocyanate adheres to stringent in-process controls and final batch testing to ensure consistent high purity and performance. We employ advanced analytical techniques, including HPLC, GC, and NMR, to verify identity, potency, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment, and we support compliance with global regulatory frameworks such as REACH.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation from atmospheric moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Melting Point	78 - 82 °C
Heavy Metals	≤ 20 ppm
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.