Description

α-Methyltyrosine Tris(trimethylsilyl) is a key silylated derivative of the amino acid analog α-methyltyrosine, primarily used as a protected intermediate in advanced organic synthesis. This compound is critical for researchers and manufacturers requiring precise control over molecular structure in sensitive reactions. It is particularly valuable for the development of pharmaceuticals, agrochemicals, and specialized fine chemicals where the trimethylsilyl groups provide essential protection and solubility characteristics.

Application

• Pharmaceutical Intermediate: Serves as a protected building block in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for neurological and cardiovascular targets.
• Peptide & Amino Acid Chemistry: Used in the synthesis of modified peptides and non-proteinogenic amino acids, where the silyl groups protect reactive hydroxyl and carboxyl functionalities.
• Agrochemical Research: Acts as a precursor in the development of novel herbicides, fungicides, and plant growth regulators.
• Analytical Reference Standard: Employed as a high-purity standard in chromatographic analysis (GC, GC-MS, HPLC) for method development and quality control.
• Material Science: Investigated for the synthesis of specialized silicon-containing polymers and hybrid organic-inorganic materials.
• Metabolite Synthesis: Used in the preparation of labeled or derivatized metabolites for pharmacokinetic and metabolic pathway studies.

Basic Information

Product Name	α-Methyltyrosine Tris(trimethylsilyl)
CAS No.	68595-74-4
Molecular Formula	C18H35NO3Si3
Molecular Weight	397.73 g/mol
Synonyms	α-Methyltyrosine Tris(trimethylsilyl) Ether; L-α-Methyltyrosine Tris(TMS); (S)-α-Methyl-p-tyrosine Tris(trimethylsilyl) Derivative; 3-(4-Hydroxyphenyl)-2-methylalanine tris(trimethylsilyl) ester; AMT-TMS; Metyrosine TMS Derivative; NSC 163120; Tris(trimethylsilyl) α-methyltyrosine
EINECS	Contact for details

Quality Control

Our α-Methyltyrosine Tris(trimethylsilyl) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, GC for residual solvents, and spectroscopic identification (IR, NMR) to ensure consistent identity and potency. Certificates of Analysis (COA) detailing all test results are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider using desiccants or an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or low-melting solid
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.