Description

Diethyl [4R-(2Alpha,4Alpha,5Beta)]-2-Ethyl-2-Methyl-1,3-Dioxolane-4,5-Dicarboxylate is a high-purity chiral dioxolane derivative, a critical building block in advanced organic synthesis. Its defined stereochemistry and functional groups make it an invaluable intermediate for creating complex, optically active molecules. This compound is essential for research and production in the pharmaceutical and fine chemical industries, where precise molecular architecture is required.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in antiviral, cardiovascular, and central nervous system (CNS) drug development.
• Asymmetric Synthesis: Serves as a precursor or auxiliary in catalytic asymmetric reactions to introduce stereogenic centers with high enantiomeric purity.
• Ligand and Catalyst Development: Used in the research and preparation of novel chiral ligands and organocatalysts for enantioselective transformations.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, agrochemicals, and flavors & fragrances requiring specific stereochemistry.
• Academic and R&D: A valuable reagent for methodological studies in organic chemistry and medicinal chemistry research programs.

Basic Information

Product Name	Diethyl [4R-(2Alpha,4Alpha,5Beta)]-2-Ethyl-2-Methyl-1,3-Dioxolane-4,5-Dicarboxylate
CAS No.	68572-78-1
Molecular Formula	C12H20O6
Molecular Weight	260.28 g/mol
Synonyms	Diethyl (4R,5R)-2-ethyl-2-methyl-1,3-dioxolane-4,5-dicarboxylate; (4R,5R)-Diethyl 2-ethyl-2-methyl-1,3-dioxolane-4,5-dicarboxylate; (4R-cis)-Diethyl 2-ethyl-2-methyl-1,3-dioxolane-4,5-dicarboxylate; Dioxolane-4,5-dicarboxylic acid, 2-ethyl-2-methyl-, diethyl ester, (4R-cis)-; Chiral dioxolane diester; Ethyl 2-ethyl-2-methyl-1,3-dioxolane-4,5-dicarboxylate (isomeric mixture)
EINECS	Contact for details

Quality Control

Our Diethyl [4R-(2Alpha,4Alpha,5Beta)]-2-Ethyl-2-Methyl-1,3-Dioxolane-4,5-Dicarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat sources and incompatible materials. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.