Description

β-Glucuronide Triacetate Methyl Ester is a key protected intermediate in organic synthesis, specifically designed for the controlled introduction of glucuronic acid moieties. Its value lies in providing a stable, reactive building block for the production of complex molecules, ensuring high regioselectivity and yield. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for developing prodrugs, targeted drug delivery systems, and advanced biochemical conjugates.

Application

• Pharmaceutical Intermediate: Critical for the synthesis of glucuronide prodrugs designed for targeted release and improved bioavailability.
• Bioconjugation Chemistry: Serves as a precursor for linking therapeutic agents to antibodies, peptides, or other targeting molecules.
• Enzyme Substrate Synthesis: Used to prepare substrates for β-glucuronidase enzymes in diagnostic assays and research tools.
• Metabolite Standard Production: Employed in the synthesis of authentic glucuronidated metabolite standards for analytical method development (LC-MS, HPLC).
• Glycochemistry Research: A vital building block for constructing complex oligosaccharides and glycoconjugates in carbohydrate chemistry.
• Prodrug Development: Enables the design of compounds where the active drug is masked by a glucuronide group for site-specific activation.

Basic Information

Product Name	β-Glucuronide Triacetate Methyl Ester
CAS No.	68450-98-6
Molecular Formula	C16H22O12
Molecular Weight	406.34 g/mol
Synonyms	Methyl (2,3,4-tri-O-acetyl-β-D-glucopyranosyluronate); Methyl 2,3,4-tri-O-acetyl-β-D-glucopyranosiduronic acid; Methyl 2,3,4-tri-O-acetyl-1-β-D-glucopyranuronate; β-D-Glucopyranosiduronic acid, methyl 2,3,4-triacetate; Glucuronic acid methyl ester triacetate; 1-O-Methyl-2,3,4-tri-O-acetyl-β-D-glucuronic acid; Triacetyl methyl β-D-glucuronide
EINECS	Contact for details

Quality Control

Our β-Glucuronide Triacetate Methyl Ester is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with detailed results from techniques including HPLC, NMR, and IR spectroscopy. Our commitment to quality supports compliance with cGMP and ISO standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent decomposition. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.