Description

o-(2,2,2-Trifluoroethyl)Hydroxylamine Hydrochloride is a specialized fluorinated building block of significant interest in advanced organic synthesis. This compound matters for its role as a key precursor in the development of novel pharmaceuticals and agrochemicals, particularly those requiring the introduction of a trifluoroethylamine moiety. Chemical manufacturers and R&D departments in the pharmaceutical, agrochemical, and material science industries need this high-purity intermediate for constructing complex molecules with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of fluorinated drugs targeting CNS disorders, oncology, and infectious diseases.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the trifluoroethyl group can improve lipophilicity and biological efficacy.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers and fluorinated materials with unique surface properties.
• Chemical Biology & Proteomics: Employed as a reagent for protein labeling, bioconjugation, and the development of chemical probes to study biological systems.
• Ligand & Catalyst Development: Useful for synthesizing novel nitrogen-containing ligands for transition metal catalysts used in asymmetric synthesis.

Basic Information

Product Name	o-(2,2,2-Trifluoroethyl)Hydroxylamine Hydrochloride
CAS No.	68401-66-1
Molecular Formula	C₂H₅ClF₃NO
Molecular Weight	163.52 g/mol
Synonyms	O-(2,2,2-Trifluoroethyl)hydroxylamine hydrochloride; N-(2,2,2-Trifluoroethoxy)amine hydrochloride; Hydroxylamine, O-(2,2,2-trifluoroethyl)-, hydrochloride; 2,2,2-Trifluoroethylhydroxylamine hydrochloride; Trifluoroethoxylamine hydrochloride; N-Hydroxy-2,2,2-trifluoroethylamine hydrochloride; (2,2,2-Trifluoroethoxy)amine hydrochloride
EINECS	Contact for details

Quality Control

Our o-(2,2,2-Trifluoroethyl)Hydroxylamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee supply reliability and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.