Description

(Z)-2-((2-Ethoxy-2-Oxoethoxy)Imino)-2-(2-Formamidothiazol-4-Yl)Acetic Acid is a key advanced pharmaceutical intermediate (API intermediate) with a distinct molecular structure featuring a thiazole ring and an acetic acid moiety. This compound is critical for the synthesis of high-value, complex molecules, particularly in the development of modern antibiotics and other active pharmaceutical ingredients. It is primarily utilized by research institutions, pharmaceutical manufacturers, and fine chemical producers engaged in the development and scale-up of novel therapeutic agents. The material's defined stereochemistry and functional groups make it an essential building block for targeted synthetic pathways.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of cephalosporin-class antibiotics and other β-lactam related compounds.
• Antibiotic Research & Development: Used as a key scaffold in medicinal chemistry for designing and testing new antibacterial agents with improved efficacy.
• Active Pharmaceutical Ingredient (API) Manufacturing: Incorporated into the production process of final drug substances requiring this specific thiazolylacetic acid derivative.
• Fine Chemical Synthesis: Employed in custom synthesis and contract manufacturing for creating complex, high-purity organic molecules.
• Biochemical Research: Utilized in studies exploring enzyme inhibition and the mechanism of action of thiazole-containing drugs.

Basic Information

Product Name	(Z)-2-((2-Ethoxy-2-Oxoethoxy)Imino)-2-(2-Formamidothiazol-4-Yl)Acetic Acid
CAS No.	68401-60-5
Molecular Formula	C₁₂H₁₅N₃O₆S
Molecular Weight	329.33 g/mol
Synonyms	7-ACA Derivative (Intermediate); 2-(2-Formamido-4-thiazolyl)-2-[(Z)-methoxyimino]acetic acid ethoxycarbonylmethyl ester; (Z)-2-(2-Formamidothiazol-4-yl)-2-[(carboxymethoxy)imino]acetic acid ethyl ester; 7-ACA Side Chain Intermediate; ATAA Ethyl Ester; Cefotaxime Intermediate; Thiazolyl Acetic Acid Derivative; 68401-60-5
EINECS	Contact for details

Quality Control

Our production of (Z)-2-((2-Ethoxy-2-Oxoethoxy)Imino)-2-(2-Formamidothiazol-4-Yl)Acetic Acid adheres to stringent quality management systems, ensuring batch-to-batch consistency for critical pharmaceutical applications. The material is manufactured under controlled conditions and undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. Certificates of Analysis (COA) detailing all specified parameters are provided with each shipment. We support compliance with cGMP and ICH guidelines for intermediates intended for API synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.