Description

(-)-Menthyl (+)-2-Pyrrolidone-5-Carboxylate is a high-purity chiral building block and intermediate of significant interest in advanced organic synthesis. Its value lies in the unique stereochemistry provided by the (-)-menthyl group, which is crucial for inducing asymmetry in target molecules. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical and fine chemical industries for developing enantiomerically pure active ingredients and specialty chemicals.

Application

• Chiral Auxiliary in Asymmetric Synthesis: Used to introduce stereocenters in the synthesis of complex pharmaceutical intermediates.
• Pharmaceutical Intermediate: Serves as a key precursor for the development of enantiomerically pure drugs, particularly in neurological and metabolic disorder research.
• Fine Chemical Synthesis: Employed in the production of specialty chemicals, flavors, and fragrances requiring specific stereochemistry.
• Academic and R&D Laboratories: A valuable reagent for methodological studies in organic chemistry and catalysis focused on stereoselective transformations.
• Peptidomimetic Research: The pyrrolidone carboxylate moiety makes it useful in constructing peptide analogs and protease inhibitors.

Basic Information

Product Name	(-)-Menthyl (+)-2-Pyrrolidone-5-Carboxylate
CAS No.	68127-22-0
Molecular Formula	C16H27NO3
Molecular Weight	281.39 g/mol
Synonyms	L-Menthyl L-pyroglutamate; (-)-Menthyl (S)-(-)-2-Pyrrolidone-5-carboxylate; (S)-5-Oxo-2-pyrrolidinecarboxylic acid (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester; L-Pyroglutamic acid L-menthyl ester; Menthyl pyroglutamate; (S)-Pyroglutamic acid (1R,2S,5R)-menthyl ester
EINECS	Contact for details

Quality Control

Our (-)-Menthyl (+)-2-Pyrrolidone-5-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with exacting research and pharmaceutical-grade standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and chiral excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong acids and incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% e.e.
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.