Description

2-Naphthyl 5-Oxo-L-Prolinate is a specialized chiral building block and intermediate of significant interest in advanced organic synthesis. Its value lies in its unique molecular architecture, which incorporates both a naphthyl ester moiety and a pyrrolidinone core, making it a versatile precursor for complex molecules. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), peptidomimetics, and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic agents, particularly those targeting neurological or metabolic pathways.
• Peptidomimetics Research: Serves as a proline derivative for constructing modified peptide structures to enhance stability, bioavailability, or receptor binding affinity.
• Asymmetric Synthesis: Utilized as a building block in catalytic asymmetric reactions to introduce stereochemical complexity into target molecules.
• Ligand and Catalyst Development: Acts as a precursor for creating novel chiral ligands or organocatalysts used in enantioselective transformations.
• Fine Chemical Production: Employed in the multi-step synthesis of high-value, low-volume specialty chemicals for agrochemical or material science applications.
• Biochemical Research: Used in studies exploring enzyme inhibition or as a substrate analog in proteomics research.

Basic Information

Product Name	2-Naphthyl 5-Oxo-L-Prolinate
CAS No.	67934-92-3
Molecular Formula	C₁₅H₁₅NO₃
Molecular Weight	257.29 g/mol
Synonyms	L-Pyroglutamic acid 2-naphthyl ester; 5-Oxo-L-proline 2-naphthyl ester; (S)-5-Oxopyrrolidine-2-carboxylic acid naphthalen-2-yl ester; 2-Naphthyl L-pyroglutamate; 2-Naphthyl (S)-5-oxopyrrolidine-2-carboxylate; Naphthalen-2-yl 5-oxo-L-prolinate
EINECS	Contact for details

Quality Control

Our 2-Naphthyl 5-Oxo-L-Prolinate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and pharmaceutical development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee traceability, consistency, and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.