Description

2-Hydroxy-3-o-Methylnaltrexone is a specialized chemical intermediate of significant interest in advanced pharmaceutical research and development. This compound is valued for its role as a key precursor in the synthesis of opioid receptor antagonists and related pharmacologically active molecules. It is primarily utilized by research institutions, pharmaceutical development laboratories, and fine chemical manufacturers engaged in the creation of new therapeutic agents targeting the central nervous system.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel opioid antagonists and related medicinal compounds.
• Biochemical Research: Used in academic and industrial research to study opioid receptor interactions and signaling pathways.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Preclinical Development: Employed in the early-stage development and optimization of new chemical entities (NCEs) with potential therapeutic applications.
• Metabolite Studies: Useful in the investigation of drug metabolism and the identification of active metabolites for certain pharmaceutical agents.

Basic Information

Product Name	2-Hydroxy-3-o-Methylnaltrexone
CAS No.	67829-18-9
Molecular Formula	C21H27NO5
Molecular Weight	373.45 g/mol
Synonyms	3-O-Methyl-2-hydroxynaltrexone; 2-Hydroxy-3-O-methylnaltrexone; 17-(Cyclopropylmethyl)-4,5α-epoxy-2-hydroxy-3-methoxy-6-oxomorphinan; Naltrexone derivative, 2-hydroxy-3-O-methyl-; 6-Keto-2-hydroxy-3-O-methylnaltrexone
EINECS	Contact for details

Quality Control

Our 2-Hydroxy-3-o-Methylnaltrexone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development purposes. Each lot is subjected to comprehensive analytical testing, including identity confirmation by spectroscopic methods and purity assessment by HPLC. A Certificate of Analysis (COA) detailing specific results for identity, assay, and impurity profile is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.