Description

n-Acetyl-2-Chloro-2-Deoxyneuraminic Acid Methyl Ester 4,7,8,9-Tetraacetate is a key protected intermediate in the synthesis of sialic acid derivatives and neuraminidase inhibitors. This compound is critical for researchers and manufacturers requiring high-purity building blocks for advanced pharmaceutical and biochemical applications. It is primarily utilized in the development of antiviral agents, glycobiology research, and the production of complex carbohydrate-based therapeutics.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel neuraminidase inhibitors and other antiviral drug candidates targeting influenza and other viruses.
• Glycobiology Research: Used as a protected sialic acid derivative for studying glycosylation processes, cell signaling, and pathogen-host interactions.
• Carbohydrate Chemistry: Serves as a versatile building block for the chemical and enzymatic synthesis of complex oligosaccharides, glycoconjugates, and glycomimetics.
• Diagnostic Reagent Development: Employed in the creation of probes and assays for detecting sialidases and studying sialic acid metabolism.
• Bioconjugation: Utilized for the site-specific modification of proteins, peptides, and other biomolecules to alter their properties or create targeted delivery systems.

Basic Information

Product Name	n-Acetyl-2-Chloro-2-Deoxyneuraminic Acid Methyl Ester 4,7,8,9-Tetraacetate
CAS No.	67670-69-3
Molecular Formula	C₂₂H₃₀ClNO₁₄
Molecular Weight	568.93 g/mol
Synonyms	Methyl (5-acetamido-4,7,8,9-tetra-O-acetyl-2-chloro-3,5-dideoxy-D-glycero-D-galacto-non-2-ulopyranosid)onate; 2-Chloro-2-deoxy-N-acetylneuraminic Acid Methyl Ester Tetraacetate; 2-Chloro-Neu5Ac Methyl Ester Tetraacetate; Peracetylated 2-Chloro-N-acetylneuraminic Acid Methyl Ester; N-Acetyl-2-chloro-2-deoxyneuraminic Acid Methyl Ester Peracetate; Sialic Acid Chloro Derivative Tetraacetate Methyl Ester
EINECS	Contact for details

Quality Control

Our n-Acetyl-2-Chloro-2-Deoxyneuraminic Acid Methyl Ester 4,7,8,9-Tetraacetate is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support compliance with cGMP and ISO 9001 standards for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.