Description

4-Piperidinecarboxylic Acid, 1-Formyl-, (-)- (9Ci) is a chiral, enantiomerically pure piperidine derivative that serves as a critical advanced pharmaceutical intermediate (API) and building block in organic synthesis. Its value lies in its defined stereochemistry and functional groups, which are essential for constructing complex molecules with high biological specificity. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of active ingredients, particularly in the development of new drugs and chiral catalysts.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and cardiovascular drug candidates.
• Asymmetric Synthesis: Used as a chiral auxiliary or precursor in asymmetric synthesis to induce stereoselectivity in complex organic reactions.
• Agrochemical Research: Serves as a precursor in the development of novel, enantiomerically pure pesticides and herbicides.
• Ligand Synthesis: Utilized for the preparation of chiral ligands used in transition metal catalysis for fine chemical production.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological development and the exploration of new synthetic pathways.
• Peptidomimetics: Acts as a constrained amino acid analog in the design and synthesis of peptide mimetics for drug discovery.

Basic Information

Product Name	4-Piperidinecarboxylic Acid, 1-Formyl-, (-)- (9Ci)
CAS No.	67659-34-1
Molecular Formula	C7H11NO3
Molecular Weight	157.17 g/mol
Synonyms	(-)-1-Formylpiperidine-4-carboxylic Acid; (R)-1-Formylpiperidine-4-carboxylic Acid; L-1-Formylpiperidine-4-carboxylic Acid; 1-Formyl-D-pipecolic Acid; 1-Formyl-D-pipecolinic Acid; (R)-Piperidine-4-carboxylic acid, 1-formyl-; 1-Formyl-4-piperidinecarboxylic acid, (-)-; 67659-34-1
EINECS	Contact for details

Quality Control

Our 4-Piperidinecarboxylic Acid, 1-Formyl-, (-)- (9Ci) is produced under a strict quality management system. Each batch undergoes rigorous analytical testing to ensure high chemical purity, correct stereochemistry, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as chiral purity (enantiomeric excess), assay, and impurity profiles. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed after opening to minimize exposure to atmospheric humidity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (ee)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.