Description

L-Phenylalanine, 4-Amino-n-[(1,1-Dimethylethoxy)Carbonyl]-, Ethyl Ester is a protected amino acid derivative, specifically a Boc-protected L-phenylalanine ethyl ester, which serves as a crucial building block in organic synthesis. This compound is valued for its role in facilitating complex peptide coupling reactions while preventing unwanted side reactions at the amino group. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel peptides, peptidomimetics, and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key precursor in the solid-phase and solution-phase synthesis of therapeutic peptides and proteins.
• Bioconjugation & Labeling: Used to introduce phenylalanine moieties into biomolecules for research, diagnostics, or drug delivery systems.
• Chemical Research & Development: Serves as a versatile starting material for constructing complex organic molecules and exploring new synthetic methodologies.
• Protecting Group Strategy: The tert-butoxycarbonyl (Boc) group allows for selective deprotection under mild acidic conditions, enabling sequential synthesis.
• Academic Research: Employed in university and institutional labs for studying peptide chemistry, enzyme substrates, and molecular recognition.
• Custom Synthesis: A fundamental component for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.

Basic Information

Product Name	L-Phenylalanine, 4-Amino-n-[(1,1-Dimethylethoxy)Carbonyl]-, Ethyl Ester
CAS No.	67630-01-7
Molecular Formula	C₁₆H₂₃NO₄
Molecular Weight	293.36 g/mol
Synonyms	Boc-L-Phenylalanine ethyl ester; N-Boc-L-Phenylalanine ethyl ester; N-(tert-Butoxycarbonyl)-L-phenylalanine ethyl ester; Ethyl (2S)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropanoate; (S)-Ethyl 2-((tert-butoxycarbonyl)amino)-3-phenylpropanoate; Boc-Phe-OEt; BOC-PHE-OET; L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-, ethyl ester
EINECS	Contact for details

Quality Control

Our Boc-L-Phenylalanine ethyl ester is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic methods for structural confirmation. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.