Description

(E)-Methyl 4-(Diethoxyphosphoryl)But-2-Enoate is a high-purity organophosphorus compound, specifically a phosphonate ester derivative of a butenoic acid. This chemical serves as a versatile and critical building block (synthon) in advanced organic synthesis, enabling the introduction of functionalized alkene and phosphonate groups. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require precise intermediates for the development of active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of complex drug molecules, particularly those requiring Horner-Wadsworth-Emmons (HWE) olefination reactions.
• Agrochemical Synthesis: Used in the production of advanced herbicides, insecticides, and plant growth regulators that incorporate phosphonate functionalities.
• Material Science Research: Acts as a monomer or cross-linking agent in the development of specialty polymers and functional materials.
• Chemical Biology Probes: Employed in the design and synthesis of enzyme inhibitors or molecular probes that target biological phosphate-binding sites.
• Academic & R&D Laboratories: A valuable reagent for methodological development in organic chemistry and catalysis studies.
• Flavor & Fragrance Industry: Potential intermediate for synthesizing specific unsaturated esters used in fragrance compositions.

Basic Information

Product Name	(E)-Methyl 4-(Diethoxyphosphoryl)But-2-Enoate
CAS No.	67629-62-3
Molecular Formula	C9H17O5P
Molecular Weight	236.20 g/mol
Synonyms	Methyl (E)-4-(Diethoxyphosphoryl)but-2-enoate; (E)-Methyl 4-(Diethoxyphosphoryl)-2-butenoate; Diethyl (E)-(3-Methoxycarbonylallyl)phosphonate; (E)-3-(Methoxycarbonyl)allylphosphonic Acid Diethyl Ester; trans-Methyl 4-(Diethoxyphosphoryl)but-2-enoate; Phosphonic acid, P-[(1E)-3-methoxy-3-oxo-1-propen-1-yl]-, diethyl ester; Diethyl (1E)-3-methoxy-3-oxoprop-1-en-1-ylphosphonate; A HWE Reagent Synthon.
EINECS	Contact for details

Quality Control

Our (E)-Methyl 4-(Diethoxyphosphoryl)But-2-Enoate is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality systems are designed to meet the stringent requirements of R&D and cGMP manufacturing environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. The container should be kept tightly sealed in a dry environment to minimize moisture uptake.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (by GC/HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Specific Gravity (20°C)	1.140 - 1.180
Refractive Index (n20D)	1.440 - 1.460

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.