Description

2'-Oxospiro[Cyclopropane-1,3'-Indoline]-2-Carboxylic Acid is a high-value spirocyclic oxindole derivative, a privileged scaffold in modern medicinal chemistry. This compound serves as a critical synthetic intermediate for developing novel small-molecule therapeutics targeting a range of diseases. It is primarily sought after by pharmaceutical R&D organizations and fine chemical manufacturers engaged in the synthesis of advanced drug candidates and bioactive molecules.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing novel drug candidates, particularly in oncology and CNS (Central Nervous System) therapeutic areas.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and library synthesis due to its spirocyclic oxindole structure.
• Proteolysis-Targeting Chimera (PROTAC) Development: Employed in the construction of linker-warhead systems for targeted protein degradation platforms.
• Kinase Inhibitor Synthesis: Serves as a precursor in the development of potent and selective kinase inhibitors.
• Chemical Biology Probes: Utilized to create tool compounds for investigating biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up under cGMP conditions.

Basic Information

Product Name	2'-Oxospiro[Cyclopropane-1,3'-Indoline]-2-Carboxylic Acid
CAS No.	67503-08-6
Molecular Formula	C12H11NO3
Molecular Weight	217.22 g/mol
Synonyms	Spiro[cyclopropane-1,3'-indoline]-2'-one-2-carboxylic acid; 2-Carboxyspiro[cyclopropane-1,3'-indolin]-2'-one; 2'-Oxo-1'H-spiro[cyclopropane-1,3'-indole]-2-carboxylic acid; 2'-Oxospiro[cyclopropane-1,3'-indolin]-2-carboxylic acid; 2-Carboxy-2'-oxospiro[cyclopropane-1,3'-indoline]; Spirocyclopropyl Oxindole-2-carboxylic Acid; 67503-08-6
EINECS	Contact for details

Quality Control

Our 2'-Oxospiro[Cyclopropane-1,3'-Indoline]-2-Carboxylic Acid is manufactured under strict quality management systems. We provide material suitable for research and development use, with specifications tailored to customer requirements. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. Custom synthesis and scale-up to meet cGMP standards for pharmaceutical applications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95% (Standard Grade)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.