Description

5-Bromo-2-Chloro-3-Nitropyridine is a high-purity halogenated and nitrated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it a versatile intermediate for constructing complex molecular architectures. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging its halogen and nitro functional groups.
• Material Science Research: Serves as a building block for creating functionalized ligands, organic semiconductors, and liquid crystal compounds.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions due to the reactive bromo and chloro substituents.
• Nucleophilic Aromatic Substitution: The chloro and nitro groups activate the pyridine ring for selective substitution reactions, enabling diverse chemical modifications.
• Chemical Research & Development: A valuable reagent for academic and industrial R&D labs exploring new heterocyclic chemistry and reaction pathways.

Basic Information

Product Name	5-Bromo-2-Chloro-3-Nitropyridine
CAS No.	67443-38-3
Molecular Formula	C5H2BrClN2O2
Molecular Weight	237.44 g/mol
Synonyms	2-Chloro-5-bromo-3-nitropyridine; 3-Nitro-5-bromo-2-chloropyridine; 5-Bromo-2-chloro-3-nitropyridine; 2-Chloro-3-nitro-5-bromopyridine; Pyridine, 5-bromo-2-chloro-3-nitro-; 5-Br-2-Cl-3-NO2-Pyridine
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-Chloro-3-Nitropyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.