Description

2-[Bis(2-Chloroethyl)Amino]-4-(Ethoxycarbonyl)Tetrahydro-2H-1,3,2-Oxazaphosphorine 2-Oxide is a specialized organophosphorus compound of significant interest in advanced chemical synthesis. This molecule matters for its role as a key intermediate in the development of targeted pharmaceutical agents and complex fine chemicals. It is primarily needed by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and life science sectors for developing novel therapeutic candidates and high-value specialty products.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel anticancer agents and other biologically active molecules.
• Antineoplastic Prodrug Development: Used in research for creating targeted chemotherapeutic prodrugs due to its specific chemical architecture.
• Medicinal Chemistry Research: A valuable scaffold for structure-activity relationship (SAR) studies in drug discovery programs.
• Fine Chemical Synthesis: Employed in the multi-step synthesis of complex, high-value organophosphorus compounds.
• Bioconjugation Chemistry: Potential use in developing linker molecules for antibody-drug conjugates (ADCs) and other targeted delivery systems.
• Agrochemical Research: Investigated as an intermediate for developing new generations of pesticides and herbicides with specific modes of action.

Basic Information

Item	Details
Product Name	2-[Bis(2-Chloroethyl)Amino]-4-(Ethoxycarbonyl)Tetrahydro-2H-1,3,2-Oxazaphosphorine 2-Oxide
CAS No.	67345-22-6
Molecular Formula	C10H19Cl2N2O4P
Molecular Weight	349.15 g/mol
Synonyms	4-(Ethoxycarbonyl)-2-[bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide; Cyclophosphamide Impurity; 1,3,2-Oxazaphosphorinane, 2-[bis(2-chloroethyl)amino]tetrahydro-4-(ethoxycarbonyl)-, 2-oxide; NSC 338258; 4-Carbethoxycyclophosphamide; Cyclophosphamide Monohydrate Related Compound; 4-Ethoxycarbonyl Cyclophosphamide
EINECS	Contact for details

Quality Control

Our 2-[Bis(2-Chloroethyl)Amino]-4-(Ethoxycarbonyl)Tetrahydro-2H-1,3,2-Oxazaphosphorine 2-Oxide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.