Description

2-[Bis(2-Chloroethyl)Amino]-3-(2-Chloroethyl)-4-Hydroperoxytetrahydro-2H-1,3,2-Oxazaphosphorine is a specialized oxazaphosphorine derivative, a class of compounds known for their significant bioactivity. This compound is of high interest in advanced pharmaceutical research and development, particularly in the synthesis of novel therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of targeted chemotherapeutics and other biologically active molecules.

Application

• Pharmaceutical Intermediate: Key building block in the research and synthesis of novel nitrogen mustard-based chemotherapeutic agents and prodrugs.
• Biochemical Research: Used as a critical reagent in studies investigating alkylating agent mechanisms, DNA cross-linking, and cell cycle inhibition.
• Anticancer Drug Development: Serves as a precursor or active moiety in the development of targeted cancer therapies, leveraging its oxazaphosphorine structure.
• Academic & Institutional Research: Employed in university and government labs for fundamental studies in medicinal chemistry and oncology.
• Process Chemistry: Used in scale-up and optimization studies for the manufacturing routes of complex active pharmaceutical ingredients (APIs).

Basic Information

Product Name	2-[Bis(2-Chloroethyl)Amino]-3-(2-Chloroethyl)-4-Hydroperoxytetrahydro-2H-1,3,2-Oxazaphosphorine
CAS No.	67292-60-8
Molecular Formula	C9H18Cl3N2O3P
Molecular Weight	363.58 g/mol
Synonyms	4-Hydroperoxy-3-(2-chloroethyl)-2-[bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine; 3-(2-Chloroethyl)-2-[bis(2-chloroethyl)amino]-4-hydroperoxytetrahydro-2H-1,3,2-oxazaphosphorine; 4-Hydroperoxy Cyclophosphamide; 4-HPCPA; 4-Hydroperoxy Cyclophosphamide; Peroxycyclophosphamide; 4-Hydroperoxy CPA; Cyclophosphamide 4-Hydroperoxide
EINECS	Contact for details

Quality Control

Our 2-[Bis(2-Chloroethyl)Amino]-3-(2-Chloroethyl)-4-Hydroperoxytetrahydro-2H-1,3,2-Oxazaphosphorine is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including HPLC purity analysis and structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) due to its sensitivity to oxidation and thermal degradation. Allow the container to reach room temperature in a desiccator before opening to prevent moisture condensation. Keep away from strong acids, bases, and reducing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.