Description

Hydroxyethylflurazepam is a benzodiazepine derivative of significant interest in pharmaceutical research and development. This compound serves as a key intermediate or reference standard in the synthesis and analytical profiling of active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions, analytical laboratories, and pharmaceutical manufacturers engaged in the development of central nervous system (CNS) therapeutics, quality control, and forensic analysis.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel benzodiazepine-based active pharmaceutical ingredients (APIs).
• Analytical Reference Standard: Used for method development, validation, and quality control testing in HPLC, GC-MS, and other chromatographic systems.
• Metabolite Studies: Employed in pharmacological and toxicological research to study drug metabolism and pharmacokinetics.
• Forensic Analysis: Serves as a certified reference material for the identification and quantification of substances in forensic toxicology.
• Biochemical Research: Used in vitro studies to investigate interactions with GABA-A receptors and related neurological pathways.
• Impurity Standard: Critical for identifying and quantifying process-related impurities and degradation products in final drug formulations.

Basic Information

Product Name	Hydroxyethylflurazepam
CAS No.	67263-28-9
Molecular Formula	C₁₇H₁₄ClFN₂O₂
Molecular Weight	332.76 g/mol
Synonyms	7-Chloro-1-(2-hydroxyethyl)-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 2-Hydroxyethylflurazepam; Flurazepam Impurity B; Flurazepam Metabolite; N-Hydroxyethylflurazepam; Ro 07-9924/001; 1,4-Benzodiazepin-2-one, 7-chloro-1-(2-hydroxyethyl)-5-(2-fluorophenyl)-1,3-dihydro-
EINECS	Contact for details

Quality Control

Our Hydroxyethylflurazepam is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for research and analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry guidelines for reference standards and pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.