Description

Ethyl [(tert-Butyldimethylsilyl)Oxy]Acetate is a versatile organosilicon reagent featuring a protected glycolic acid moiety. This compound is valued for its role as a key synthetic building block, enabling the controlled introduction of oxygenated functional groups under mild conditions. It is primarily sought after by research chemists and process development teams in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A crucial synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in the construction of ester and ether linkages in drug candidates.
• Peptide & Carbohydrate Chemistry: Used as a protected hydroxyacetic acid equivalent in solid-phase and solution-phase synthesis of modified peptides and complex sugars.
• Agrochemical Synthesis: Serves as a building block for creating herbicidal and fungicidal compounds with specific ester functionalities.
• Polymer & Material Science: Employed in the production of specialty monomers and siloxane-based polymers for coatings and functional materials.
• Organic Synthesis Reagent: Acts as a stable, nucleophilic enolate precursor for alkylation and aldol reactions in complex molecule assembly.
• Protecting Group Strategy: The tert-butyldimethylsilyl (TBDMS) group provides robust protection for alcohols and acids during multi-step syntheses.

Basic Information

Product Name	Ethyl [(tert-Butyldimethylsilyl)Oxy]Acetate
CAS No.	67226-78-2
Molecular Formula	C10H22O3Si
Molecular Weight	218.37 g/mol
Synonyms	Ethyl (tert-Butyldimethylsilyloxy)acetate; Ethyl [(tert-Butyldimethylsilyl)oxy]acetate; Acetic acid, 2-[(1,1-dimethylethyl)dimethylsilyl]oxy]-, ethyl ester; Ethyl 2-((tert-butyldimethylsilyl)oxy)acetate; TBDMS-glycolic acid ethyl ester; 2-[(tert-Butyldimethylsilyl)oxy]acetic Acid Ethyl Ester; Glycolic acid, O-(tert-butyldimethylsilyl)-, ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl [(tert-Butyldimethylsilyl)Oxy]Acetate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatography (HPLC, GC) and spectroscopic methods (NMR, IR), to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed batch-specific results are provided to guarantee consistency and traceability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.