Description

tert-Butyldimethylsilyl-2-Methyl-1,3-Dioxolane-2-Propionate is a specialized organosilicon protecting group reagent, crucial for the selective protection of sensitive functional groups in complex organic syntheses. Its primary value lies in providing robust, orthogonal protection for carbonyl functionalities, particularly in multi-step synthesis where precise control over reaction sequences is paramount. This high-purity intermediate is essential for research and production chemists in the pharmaceutical, agrochemical, and advanced materials sectors, enabling the synthesis of complex molecules with high fidelity.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for protecting carbonyl groups during peptide and complex molecule assembly.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides where selective protection strategies are required.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances requiring sophisticated synthetic pathways.
• Academic & Industrial R&D: A valuable tool for method development and exploratory synthesis in organic chemistry laboratories.
• Peptide Chemistry: Facilitates the protection of specific amino acid side chains or backbone functionalities during solid-phase or solution-phase peptide synthesis.
• Material Science Precursor: Serves as a precursor for silicon-containing monomers or polymers with tailored properties.

Basic Information

Product Name	tert-Butyldimethylsilyl-2-Methyl-1,3-Dioxolane-2-Propionate
CAS No.	67226-75-9
Molecular Formula	C13H26O4Si
Molecular Weight	274.43 g/mol
Synonyms	2-Methyl-2-[(tert-butyldimethylsilyl)oxy]methyl-1,3-dioxolane-4-propionate; TBDMS-2-Methyl-1,3-Dioxolane-2-Propionate; (2-Methyl-1,3-dioxolan-2-yl)methyl tert-butyldimethylsilyl propionate; 2-[(tert-Butyldimethylsilyl)oxymethyl]-2-methyl-1,3-dioxolane-4-propanoate; tert-Butyldimethylsilyl (2-methyl-1,3-dioxolan-2-yl)methyl propionate
EINECS	Contact for details

Quality Control

Our tert-Butyldimethylsilyl-2-Methyl-1,3-Dioxolane-2-Propionate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including NMR, HPLC, and GC analysis, to confirm identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support compliance needs for cGMP, ISO, and other relevant regulatory frameworks upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.