Description

Methyl 2-Iodo-2-Methylpropionate is a versatile halogenated ester building block, specifically an α-iodo ester, valued for its reactivity in organic synthesis. Its structure makes it a crucial intermediate for introducing quaternary carbon centers and functional groups via nucleophilic substitution and radical reactions. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity intermediates for complex molecule construction.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly those containing quaternary carbon centers or requiring further functionalization.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and plant growth regulators where its reactive iodine atom facilitates coupling reactions.
• Organic Synthesis Reagent: Employed in radical chain reactions and as an alkylating agent in C-C bond formation for complex natural product and fine chemical synthesis.
• Polymer Chemistry: Serves as an initiator or chain-transfer agent in controlled radical polymerization (e.g., ATRP - Atom Transfer Radical Polymerization) to create polymers with specific architectures.
• Material Science Research: Utilized in the development of novel organic materials, liquid crystals, and specialty chemicals requiring tailored molecular structures.
• Cross-Coupling Reactions: Acts as a substrate in various metal-catalyzed cross-coupling reactions (e.g., with palladium or nickel catalysts) to form new carbon-carbon bonds.

Basic Information

Product Name	Methyl 2-Iodo-2-Methylpropionate
CAS No.	67194-53-0
Molecular Formula	C5H9IO2
Molecular Weight	228.03 g/mol
Synonyms	Methyl α-Iodoisobutyrate; 2-Iodo-2-methylpropionic Acid Methyl Ester; Methyl 2-Iodoisobutyrate; Methyl 2-Iodo-2-methylpropanoate; Iodomethyl Isobutyrate; Neopentyl Iodide Ester; Methyl Ester of 2-Iodo-2-methylpropionic Acid
EINECS	Contact for details

Quality Control

Our Methyl 2-Iodo-2-Methylpropionate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chromatography (HPLC/GC) and spectroscopic methods (NMR, IR), to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support compliance with cGMP and ICH guidelines for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong acids and incompatible organic solvents. Due to its light-sensitive nature, containers should be amber-colored or stored in dark conditions. Handle and store under an inert atmosphere (e.g., nitrogen) for long-term stability to minimize potential decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Gravity	1.60 - 1.65 g/mL @ 20°C
Refractive Index	1.480 - 1.490 @ 20°C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.