Description

1-(Chloromethyl)-4-Fluoro-2-Isocyanatobenzene is a versatile aromatic isocyanate building block characterized by its reactive chloromethyl and isocyanate functional groups. This bifunctional nature makes it a critical intermediate for synthesizing advanced chemical architectures, particularly in the pharmaceutical and agrochemical sectors. It is primarily sought after by R&D chemists and process development scientists for constructing active pharmaceutical ingredients (APIs), advanced crop protection agents, and specialty polymers.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and other small-molecule therapeutic classes.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, leveraging its fluorine and aromatic structure.
• Polymer & Resin Modifier: Serves as a cross-linking agent or chain extender in polyurethane and specialty polymer systems to introduce specific chemical functionality.
• Ligand & Chelator Precursor: Facilitates the creation of complex organic ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Research (R&D): A valuable reagent for medicinal chemistry and process chemistry research due to its dual reactivity.
• Dye & Pigment Intermediate: Used in the synthesis of specialized colorants and functional dyes.

Basic Information

Item	Details
Product Name	1-(Chloromethyl)-4-Fluoro-2-Isocyanatobenzene
CAS No.	67098-97-9
Molecular Formula	C8H5ClFNO
Molecular Weight	185.58 g/mol
Synonyms	4-Fluoro-2-isocyanato-1-(chloromethyl)benzene; 2-Isocyanato-5-fluorobenzyl chloride; 5-Fluoro-2-(chloromethyl)phenyl isocyanate; 1-Chloromethyl-4-fluoro-2-isocyanatobenzene; 2-Isocyanato-α-chloro-5-fluorotoluene; 5-Fluorobenzyl chloride-2-isocyanate; (5-Fluoro-2-isocyanatophenyl)methyl chloride
EINECS	Contact for details

Quality Control

Our 1-(Chloromethyl)-4-Fluoro-2-Isocyanatobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.