Description

Isopropyl 2-Propoxyethyl 1,4-Dihydro-2,6-Dimethyl-4-(3-Nitrophenyl)Pyridine-3,5-Dicarboxylate is a high-purity, specialized pharmaceutical intermediate of significant commercial interest. This compound is valued for its role as a key building block in the synthesis of advanced active pharmaceutical ingredients (APIs), particularly within the cardiovascular therapeutic class. It is primarily sought by pharmaceutical manufacturers and advanced R&D laboratories engaged in the development and production of next-generation medications.

Application

• Pharmaceutical Intermediate: Critical precursor in the synthesis of complex dihydropyridine-based active pharmaceutical ingredients (APIs).
• Cardiovascular Drug Research: Key building block for the development and scale-up of calcium channel blockers and related therapeutic agents.
• Chemical Synthesis: Used in advanced organic synthesis for constructing complex molecular architectures with specific pharmacological activity.
• Process Development: Serves as a reference standard and starting material for optimizing manufacturing routes in GMP environments.
• Analytical Reference Standard: Employed in quality control laboratories for method development, validation, and impurity profiling.

Basic Information

Product Name	Isopropyl 2-Propoxyethyl 1,4-Dihydro-2,6-Dimethyl-4-(3-Nitrophenyl)Pyridine-3,5-Dicarboxylate
CAS No.	67078-97-1
Molecular Formula	C24H30N2O7
Molecular Weight	458.51 g/mol
Synonyms	Isopropyl 2-Propoxyethyl 4-(3-Nitrophenyl)-2,6-Dimethyl-1,4-Dihydropyridine-3,5-Dicarboxylate; 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid, 3-(2-propoxyethyl) 5-(1-methylethyl) ester; 4-(3-Nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid isopropyl 2-propoxyethyl ester; Felodipine Impurity; Felodipine Related Compound; Dihydropyridine Derivative CAS 67078-97-1
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and traceability. Quality is verified through comprehensive analytical techniques including HPLC, GC, and NMR to meet exacting customer specifications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment, supporting regulatory filings and GMP compliance.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at a controlled room temperature (15-25°C). This material is light-sensitive and easily oxidized; prolonged exposure to air, light, or elevated temperatures should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.