Description

5-(1,2-Dimethylpropyl)-5-Ethylbarbituric Acid CAS NO 66941-17-1 is a specialized barbiturate derivative, a class of compounds historically significant in medicinal chemistry. This high-purity intermediate is crucial for pharmaceutical research and development, particularly in the synthesis of novel therapeutic agents and reference standards. It serves the needs of pharmaceutical manufacturers, contract research organizations (CROs), and advanced academic research laboratories focused on central nervous system (CNS) drug discovery and analytical method development.

Application

• Pharmaceutical Intermediate: Key building block in the research-scale synthesis of barbiturate-based active pharmaceutical ingredients (APIs) and their analogs.
• Reference Standard: Used as a certified reference material (CRM) in analytical laboratories for method validation, quality control, and regulatory compliance testing.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies aimed at developing new CNS-targeting compounds.
• Biochemical Research: Utilized in studies investigating the mechanism of action of barbiturates on GABAA receptors and other biological targets.
• Impurity Standard: Employed to identify and quantify related substances in the quality control of other barbiturate drugs.

Basic Information

Item	Details
Product Name	5-(1,2-Dimethylpropyl)-5-Ethylbarbituric Acid
CAS No.	66941-17-1
Molecular Formula	C11H18N2O3
Molecular Weight	226.27 g/mol
Synonyms	5-Ethyl-5-(1,2-dimethylpropyl)barbituric acid; 5-(1,2-Dimethylpropyl)-5-ethyl-2,4,6(1H,3H,5H)-pyrimidinetrione; Butalbital Impurity; Butalbital Related Compound A; 5-Allyl-5-isobutylbarbituric acid derivative (structural); Contact for details on additional trade names and research codes.
EINECS	Contact for details

Quality Control

Our 5-(1,2-Dimethylpropyl)-5-Ethylbarbituric Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and tests for residual solvents and heavy metals. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be opaque or stored in dark conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.