Description

6''-Fluoro-2'',3''-Dihydro-2H,5H-Spiro[Imidazolidine-4,4''-Thiochromene]-2,5-Dione 1'',1''-Dioxide is a high-value, complex heterocyclic compound featuring a unique spiro-fused imidazolidine and thiochromene dioxide structure. This compound is of significant interest in advanced organic synthesis, particularly for pharmaceutical research and development. It serves as a critical synthetic intermediate or building block for medicinal chemists targeting novel bioactive molecules, especially in the areas of central nervous system (CNS) and enzyme inhibitor therapeutics.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its complex, drug-like scaffold.
• Chemical Biology Probes: Serves as a core structure for developing enzyme inhibitors or receptor modulators used in biological pathway analysis.
• Advanced Organic Synthesis: Employed in methodological development for constructing complex spirocyclic and fused heterocyclic systems.
• Contract Research & Development (CRO): Supplied to research organizations specializing in custom synthesis and early-stage drug discovery.
• Academic Research: Utilized in university laboratories for studies in synthetic methodology and heterocyclic chemistry.

Basic Information

Product Name	6''-Fluoro-2'',3''-Dihydro-2H,5H-Spiro[Imidazolidine-4,4''-Thiochromene]-2,5-Dione 1'',1''-Dioxide
CAS No.	66892-63-5
Molecular Formula	C₁₁H₉FN₂O₄S
Molecular Weight	284.26 g/mol
Synonyms	6''-Fluoro-2'',3''-dihydro-2H,5H-spiro[imidazolidine-4,4''-thiochromene]-2,5-dione 1'',1''-dioxide; 6-Fluoro-2,3-dihydro-2H,5H-spiro[imidazolidine-4,4-thiochromene]-2,5-dione 1,1-dioxide; Spiro[imidazolidine-4,4'-thiochromene]-2,5-dione, 6'-fluoro-2',3'-dihydro-1',1'-dioxide; 66892-63-5; 6'-Fluoro-2',3'-dihydrospiro[imidazolidine-4,4'-thiochromene]-2,5-dione 1',1'-dioxide
EINECS	Contact for details

Quality Control

Our 6''-Fluoro-2'',3''-Dihydro-2H,5H-Spiro[Imidazolidine-4,4''-Thiochromene]-2,5-Dione 1'',1''-Dioxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis, to ensure it meets the exacting standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.