Description

(3S)-5-(2-Fluorophenyl)-1,3-Dihydro-1,3α-Dimethyl-7-Nitro-2H-1,4-Benzodiazepine-2-One is a high-purity, chiral benzodiazepine derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical synthetic intermediate or reference standard for the development of novel therapeutic agents targeting the central nervous system. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the synthesis of complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel benzodiazepine-based active pharmaceutical ingredients (APIs).
• Reference Standard: Used for analytical method development, validation, and quality control in pharmaceutical manufacturing.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore new neuropharmacological agents.
• Process Chemistry: Serves as a starting material or intermediate in the development and scale-up of synthetic routes for complex molecules.
• Academic Research: Utilized in university and institutional labs for studies in organic synthesis and pharmacology.

Basic Information

Product Name	(3S)-5-(2-Fluorophenyl)-1,3-Dihydro-1,3α-Dimethyl-7-Nitro-2H-1,4-Benzodiazepine-2-One
CAS No.	66855-85-4
Molecular Formula	C₁₇H₁₄FN₃O₃
Molecular Weight	327.31 g/mol
Synonyms	(S)-5-(2-Fluorophenyl)-1,3-dihydro-1,3-dimethyl-7-nitro-2H-1,4-benzodiazepin-2-one; (3S)-5-(2-Fluorophenyl)-1,3-dihydro-1,3α-dimethyl-7-nitro-2H-1,4-benzodiazepine-2-one; 7-Nitro-5-(2-fluorophenyl)-1,3-dihydro-1,3α-dimethyl-2H-1,4-benzodiazepin-2-one (3S)-; (S)-Enantiomer of Ro 07-9749; A Chiral 1,4-Benzodiazepine Derivative
EINECS	Contact for details

Quality Control

Our (3S)-5-(2-Fluorophenyl)-1,3-Dihydro-1,3α-Dimethyl-7-Nitro-2H-1,4-Benzodiazepine-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with exacting standards for research and development use. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.