Description

Threonine tert-Butyl Ester is a protected amino acid derivative of significant importance in advanced organic synthesis. This compound serves as a crucial chiral building block, enabling the controlled construction of complex peptide chains and other bioactive molecules. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for the development of novel therapeutic agents and fine chemicals.

Application

• Pharmaceutical Intermediates: A key chiral synthon in the synthesis of peptide-based drugs, antibiotics, and other active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) where the tert-butyl ester group provides orthogonal protection for the carboxylic acid functionality.
• Bioconjugation & Linker Chemistry: Employed in the preparation of labeled peptides, peptide-drug conjugates, and other biomolecular constructs for research and diagnostics.
• Asymmetric Synthesis: Acts as a starting material or intermediate in asymmetric catalytic processes to introduce the threonine moiety with high stereochemical fidelity.
• Chemical Biology Research: Utilized in academic and industrial R&D for studying protein-protein interactions, enzyme mechanisms, and developing enzyme inhibitors.
• Fine Chemical Production: Serves as a precursor in the manufacture of specialized fine chemicals, flavors, and fragrances requiring specific stereochemistry.

Basic Information

Product Name	Threonine tert-Butyl Ester
CAS No.	66748-90-1
Molecular Formula	C8H17NO3
Molecular Weight	175.23 g/mol
Synonyms	L-Threonine tert-butyl ester; (2S,3R)-2-Amino-3-hydroxybutanoic acid tert-butyl ester; tert-Butyl L-threoninate; O-tert-Butyl-L-threonine; H-Thr(OtBu)-OH; Threonine, O-tert-butyl-; Threonine, tert-butyl ester; Boc-Thr-OH (Note: often associated with Boc-protected version, but listed as common search term)
EINECS	Contact for details

Quality Control

Our Threonine tert-Butyl Ester is produced under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data to support its use in critical applications. Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles are available for every batch upon request, ensuring full traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.