Description

n-α-Z-L-Arginine 4-Nitrobenzyl Ester Hydrochloride is a protected arginine derivative, a crucial building block in peptide synthesis and pharmaceutical research. Its value lies in providing a stable, activated form of the arginine side chain, enabling precise and efficient coupling reactions. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries developing novel peptide-based therapeutics and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the controlled incorporation of arginine residues into peptide chains.
• Solution-Phase Peptide Synthesis: Used in classical peptide coupling methodologies to construct specific peptide sequences.
• Pharmaceutical Intermediate: Serves as a critical precursor in the research and development of peptide drugs, including hormone analogs and enzyme inhibitors.
• Bioconjugation and Labeling: The reactive ester group facilitates the attachment of peptides to other molecules, surfaces, or probes for diagnostic and research applications.
• Biochemical Research: Employed in studying enzyme-substrate interactions, protein function, and signal transduction pathways that involve arginine.
• Custom Peptide Service: A fundamental reagent for CROs (Contract Research Organizations) and CDMOs (Contract Development and Manufacturing Organizations) offering bespoke peptide production.

Basic Information

Product Name	n-α-Z-L-Arginine 4-Nitrobenzyl Ester Hydrochloride
CAS No.	66735-62-4
Molecular Formula	C20H24N6O6 • HCl
Molecular Weight	488.91 g/mol
Synonyms	Z-Arg(NO2)-OBzl • HCl; Nα-Carbobenzoxy-Nω-nitro-L-arginine 4-nitrobenzyl ester hydrochloride; Nα-Z-Nω-NO2-L-Arg-ONb • HCl; Benzyl N-[(benzyloxy)carbonyl]-Nω-nitro-L-argininate 4-nitrobenzyl ester hydrochloride; L-Arginine, N2-[(phenylmethoxy)carbonyl]-N5-(nitroamino)-, 4-nitrophenyl ester, hydrochloride (1:1); Z-Arg(NO2)-ONB HCl; CBZ-Nω-nitro-L-arginine 4-nitrobenzyl ester hydrochloride
EINECS	Contact for details

Quality Control

Our n-α-Z-L-Arginine 4-Nitrobenzyl Ester Hydrochloride is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic identification (NMR, IR). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]D20	Contact for details
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.