Description

n-(Pyridin-2-Yl)-2-Bromoacetamide CAS NO 66642-53-3 is a specialized bromoacetamide derivative featuring a pyridine moiety, serving as a versatile and reactive synthetic building block. Its core value lies in its bifunctional reactivity, where the bromoacetamide group acts as an efficient alkylating agent and the pyridine ring can coordinate to metals or participate in further heterocyclic synthesis. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries who require high-purity intermediates for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of potential drug candidates, especially those targeting neurological disorders or as kinase inhibitors.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides.
• Ligand and Complex Formation: The pyridine nitrogen makes it a useful starting material for creating chelating ligands in coordination chemistry and catalysis.
• Peptidomimetic and Bioconjugation Chemistry: The reactive bromoacetamide group is employed for selective alkylation of thiol groups in cysteine residues, useful in bioconjugation and probe development.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of functional polymers and smart materials.
• Chemical Biology Tool: Utilized in activity-based protein profiling (ABPP) and other probe-based discovery platforms.

Basic Information

Product Name	n-(Pyridin-2-Yl)-2-Bromoacetamide
CAS No.	66642-53-3
Molecular Formula	C7H7BrN2O
Molecular Weight	215.05 g/mol
Synonyms	2-Bromo-N-(pyridin-2-yl)acetamide; N-(2-Pyridyl)-2-bromoacetamide; 2-Bromoacetopyridine-2-amide; α-Bromoacetopyridine-2-amide; Bromoacetic acid 2-pyridylamide; Pyridine-2-carboxamide, N-(bromoacetyl)-; Acetamide, 2-bromo-N-2-pyridinyl-
EINECS	Contact for details

Quality Control

Our n-(Pyridin-2-Yl)-2-Bromoacetamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.