Description

Propiomazinehydrochloride CAS NO 66487-09-0 is a pharmaceutical-grade active pharmaceutical ingredient (API) belonging to the phenothiazine class of compounds. This compound is critical for ensuring the efficacy and safety of finished pharmaceutical formulations. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of therapeutic agents.

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription medications.
• Sedative and Premedication Formulations: Key component in injectable solutions used for pre-anesthetic sedation and as an adjunct to anesthesia.
• Antihistamine Preparations: Utilized in formulations targeting allergic reactions and pruritus.
• Veterinary Medicine: Incorporated into sedative and antiemetic products for animal healthcare.
• Clinical Research: Serves as a reference standard and raw material in pharmacological studies and drug development pipelines.
• Controlled Drug Substance Manufacturing: Used under strict regulatory oversight for producing scheduled pharmaceutical products.

Basic Information

Item	Details
Product Name	Propiomazine Hydrochloride
CAS No.	66487-09-0
Molecular Formula	C20H24N2OS • HCl
Molecular Weight	376.94 g/mol
Synonyms	Propiomazine HCl; Propavan; 1-(10-(2-Dimethylaminopropyl)phenothiazin-2-yl)propan-1-one hydrochloride; Dihydrochlorothiazide (obsolete); Propionylpromazine Hydrochloride; Largon (brand name); Domar (brand name)
EINECS	Contact for details

Quality Control

Our Propiomazine Hydrochloride is manufactured under strict quality management systems, targeting compliance with pharmaceutical standards (USP/EP). Every batch undergoes comprehensive analytical testing including identification, assay, impurity profiling, and residual solvent analysis. A Certificate of Analysis (COA) documenting all test results against predefined specifications is provided with each shipment to ensure traceability and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The container should be kept in a well-ventilated area and protected from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.