Description

3,4-Di(tert-Butoxy)-3-Cyclobutene-1,2-Dione is a specialized, high-purity cyclobutenedione derivative, a key building block in advanced organic synthesis. This compound matters for its unique reactivity as a protected or masked squarate equivalent, enabling the controlled construction of complex molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for synthesizing novel active ingredients and functional materials. Its specific structure offers precise control in reactions where traditional dicarbonyl compounds may lack selectivity.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of complex drug candidates, particularly those requiring cyclobutane or cyclobutene ring systems.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides with unique modes of action.
• Organic Ligand & Catalyst Development: Acts as a starting material for creating novel chelating ligands and organocatalysts used in asymmetric synthesis.
• Polymer & Materials Science: Employed in the synthesis of monomers for specialty polymers, including those with photonic or electronic properties.
• Academic & Industrial Research: A valuable reagent for methodology development and exploring new reaction pathways in organic chemistry.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes.

Basic Information

Product Name	3,4-Di(tert-Butoxy)-3-Cyclobutene-1,2-Dione
CAS No.	66478-66-8
Molecular Formula	C12H20O4
Molecular Weight	228.29 g/mol
Synonyms	3,4-Di-tert-butoxy-3-cyclobutene-1,2-dione; Di-tert-butyl squarate; 3,4-Bis(tert-butoxy)cyclobut-3-ene-1,2-dione; Squaric acid di-tert-butyl ester; 1,2-Di-tert-butoxy-1,2-dihydroxycyclobut-3-ene-1,2-dione (tautomer); DTBSQ; tert-Butyl squarate
EINECS	Contact for details

Quality Control

Our 3,4-Di(tert-Butoxy)-3-Cyclobutene-1,2-Dione is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring traceability and consistency for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Recommended storage temperature is between 2°C and 8°C (refrigerated) for long-term stability, although the material is typically stable at controlled room temperature for shorter periods. Keep container tightly sealed when not in use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.