Description

L-Glutamine, Phenylmethyl Ester is a protected amino acid derivative where the carboxylic acid group is masked as a benzyl ester. This chemical modification is crucial for peptide synthesis, as it prevents unwanted side reactions during the coupling process. It serves as a key building block for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing novel peptides and therapeutic agents.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental protected amino acid for the controlled assembly of peptide chains.
• Solution-Phase Peptide Synthesis: Used in classical coupling strategies for producing custom peptides and peptide fragments.
• Pharmaceutical Intermediates: Serves as a critical precursor in the synthesis of peptide-based active pharmaceutical ingredients (APIs).
• Biochemical Research: Employed in studies involving glutamine metabolism, enzyme substrates, and the structure-activity relationships of peptides.
• Combinatorial Chemistry: A valuable component in libraries for drug discovery and high-throughput screening.
• Production of Glutamine-Containing Peptides: Specifically used to incorporate the glutamine residue into sequences for nutritional, cosmetic, or therapeutic peptides.

Basic Information

Product Name	L-Glutamine, Phenylmethyl Ester
CAS No.	66449-94-3
Molecular Formula	C₁₂H₁₆N₂O₃
Molecular Weight	236.27 g/mol
Synonyms	L-Glutamine benzyl ester; H-Gln-OBzl; Benzyl L-glutaminate; (S)-2-Amino-4-carbamoylbutanoic acid benzyl ester; N2-[(Benzyloxy)carbonyl]-L-glutamine; Z-Gln-OH (common abbreviation); Glutamine benzyl ester tosylate salt (related salt form); Fmoc-Gln-OBzl (Fmoc-protected variant)
EINECS	Contact for details

Quality Control

Our L-Glutamine, Phenylmethyl Ester is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the high standards required for peptide synthesis. A Certificate of Analysis (COA) detailing specific results for identity, assay, and purity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using a desiccant.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]²⁰D	+15.0° to +20.0° (c=1 in acetic acid)
Chiral Purity (HPLC)	≥99.0% L-isomer
Loss on Drying	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.